Acetaminophen (Tylenol, Panadol, Ofirmev (IV formulation))
Other Medications · Approved since 1955
Description
Acetaminophen is a widely used analgesic and antipyretic medication that serves as a cornerstone of supportive care in colorectal cancer treatment. It provides effective pain management for mild to moderate cancer-related pain and helps control fever associated with cancer or its treatments. In the CRC setting, acetaminophen is frequently used as part of multimodal pain management protocols and may be incorporated into enhanced recovery after surgery (ERAS) pathways for patients undergoing colorectal resection procedures.
Mechanism of Action
Acetaminophen exerts its analgesic and antipyretic effects primarily through inhibition of cyclooxygenase (COX) enzymes in the central nervous system, particularly COX-2, reducing prostaglandin synthesis in the brain and spinal cord. Unlike NSAIDs, it has minimal peripheral anti-inflammatory activity and does not significantly inhibit COX enzymes in peripheral tissues. The drug also modulates pain pathways through interactions with the endocannabinoid system and serotonergic pathways.
Molecular Targets
Side Effects
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
Quick Info
| Brand Name | Tylenol, Panadol, Ofirmev (IV formulation) |
| Category | Other Medications |
 Status | FDA Approved |
 EMA Status | EMA Approved |
 Spain Access | Funded by SNS other indication |
| Administration | Oral, IV |
| Year Approved | 1955 |
| Clinical Trials | 2 |
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Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.