Loperamide
Clinical Trials Overview
2 trials found
About Loperamide
Loperamide is an opioid receptor agonist antidiarrheal medication used as supportive care in colorectal cancer patients to manage treatment-related diarrhea. It is commonly prescribed to control diarrhea caused by chemotherapy, targeted therapies, or immunotherapy-induced colitis. Loperamide helps maintain patient quality of life and allows continuation of cancer treatment by effectively managing gastrointestinal side effects.
Category
Other Medications
Brand Name
Imodium, Imodium A-D, Kaopectate II
Mechanism
Loperamide binds to mu-opioid receptors in the intestinal wall, slowing intestinal motility and increasing water and electrolyte absorption from the bowel. This mechanism reduces stool frequency and improves stool consistency without significant central nervous system effects due to poor blood-brain barrier penetration.
2
Total Trials
1
Recruiting
0
Active
1
Completed
41
Total Enrollment
1
Countries
med_trials_active_sites
Recruiting sites
1 countries
Phase:
NCT04038619
Phase 1
Recruiting
40 patients
Medications:
Loperamide
This trial studies how well fecal microbiota transplantation works in treating diarrhea or colitis (inflammation of the intestines) that is caused by certain types of medications (called immune-checkpoint inhibitors) in patients with genitourinary ca...
United States
NCT04172597
Phase 2
Completed
1 patients
Medications:
Loperamide
This is a Phase 2, open-label, multicenter study whose principal objectives are to evaluate the efficacy and safety/tolerability of poziotinib in five cohorts of 30 previously-treated patients each.
United States