Sevoflurane
Clinical Trials Overview
4 trials found
About Sevoflurane
Sevoflurane is a halogenated inhalational anesthetic agent used during surgical procedures for colorectal cancer patients. This volatile anesthetic provides general anesthesia during tumor resection surgeries and other colorectal cancer-related procedures. It belongs to the class of fluorinated ether anesthetics and is administered via inhalation through specialized anesthesia equipment. Research is examining whether the choice of volatile anesthetics like sevoflurane versus intravenous anesthetics may influence perioperative outcomes and postoperative pain management in cancer surgery.
Category
Other Medications
Brand Name
Ultane, Sevorane
Mechanism
Sevoflurane produces general anesthesia by enhancing inhibitory neurotransmission through gamma-aminobutyric acid (GABA) receptors and glycine receptors while simultaneously blocking excitatory sodium and calcium channels in the central nervous system. This dual mechanism results in dose-dependent depression of neuronal activity, leading to unconsciousness, amnesia, and reduced autonomic reflexes. The agent is rapidly absorbed through the lungs and quickly eliminated through pulmonary ventilation due to its low blood-gas solubility coefficient.
4
Total Trials
0
Recruiting
1
Active
3
Completed
1,599
Total Enrollment
4
Countries
Phase:
NCT04259398
Not Applicable
Active
797 patients
Medications:
Propofol
Sevoflurane
This study investigates the influence of type of anesthesia on survival and recurrence rate in patients receiving colon cancer surgery. The participants will be allocated to either the TIVA group and the inhalation group.
South Korea
NCT06017141
Phase 2
Completed
80 patients
Medications:
Propofol
Sevoflurane
This trial evaluates how inhalational anesthesia (drawn in through the lungs) and total intravenous anesthesia (TIVA) (through a needle in a vein in the arm) change the body's ability to recover from surgery or whether they impact the immune system i...
United States
NCT04316013
Phase 3
Completed
254 patients
VAPOR-C is a randomised study of the impact of IV versus inhaled anaesthesia (propofol versus sevoflurane) and lidocaine versus no lidocaine on duration of disease free survival inpatients with either colorectal or non small cell lung cancer.
United States, Australia, New Zealand
NCT04239794
Not Applicable
Completed
468 patients
Medications:
Propofol
Sevoflurane
The investigators designed a multi-center prospective randomized controlled trial to study the influence of the type of anesthesia on postoperative pain after laparoscopic colorectal cancer surgery. Half of the participants will be anesthetized with ...
South Korea