SHR-8068 (Not yet branded)

Other Medications

US Experimental IV 4 Clinical Trials
Unknown specific target

Description

SHR-8068 is a novel therapeutic compound developed for treatment of microsatellite stable (MSS) colorectal cancer, specifically designed for combination therapy approaches. This agent is being utilized in Phase I and Phase II clinical protocols targeting advanced colorectal cancer patients, particularly those with MSS tumors who typically have limited immunotherapy options. The compound has been evaluated in combination with anti-tumor agents including adbelizumab and BP102 to enhance therapeutic efficacy in metastatic disease.

Mechanism of Action

Based on its clinical development pattern in MSS colorectal cancer, SHR-8068 appears to target pathways involved in tumor microenvironment modulation or immune system activation. The specific molecular mechanism involves interaction with cellular targets that can potentially overcome the immunotherapy resistance commonly seen in MSS colorectal tumors.

Molecular Targets

Side Effects

Fatigue Nausea Diarrhea Decreased appetite Skin reactions Laboratory abnormalities Infusion-related reactions Immune-related adverse events

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT07454720 Phase 2
Recruiting
A Clinical Study of Adebrelimab in Combination With SHR-8068 and Chemoradiotherapy as Perioperative Therapy for Locally Advanced Rectal Cancer
China
NCT07503639 Phase 2
Not yet recruiting
Umbrella Trial of Neoadjuvant Therapy for Locally Advanced Colorectal Cancer
NCT07071714 Phase 2
Active, not recruiting
A Phase II Study of SHR-8068 Injection in Combination With Anti-tumor Therapies in Colorectal Cancer
China
NCT06373133 Phase 1
Not yet recruiting
SHR-8068 Combined With Adbelizumab and BP102 in the Treatment of Advanced Colorectal Cancer