SC-201 (Not yet branded)

Other Medications

US Experimental Oral 2 Clinical Trials
HDAC1 HDAC3 HDAC6

Description

SC-201 (resminostat) is a histone deacetylase inhibitor that has been evaluated in advanced colorectal carcinoma. This epigenetic modifier works by altering gene expression patterns in cancer cells. It belongs to the class of HDAC inhibitors that target chromatin remodeling mechanisms in solid tumors.

Mechanism of Action

Resminostat selectively inhibits histone deacetylases, particularly HDAC1, HDAC3, and HDAC6, leading to increased acetylation of histone and non-histone proteins. This epigenetic modification results in altered gene expression, promoting cancer cell cycle arrest, differentiation, and apoptosis while potentially enhancing immune recognition of tumor cells.

Molecular Targets

Side Effects

Fatigue Nausea Diarrhea Decreased appetite Thrombocytopenia Anemia Elevated liver enzymes QT prolongation

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT05973487 med_phase_prefix1
Active, not recruiting
A Basket Study of Customized Autologous TCR-T Cell Therapies in Patients With Locally Advanced (Unresectable) or Metastatic Solid Tumors
United States
NCT01277406 med_phase_prefix1
Archived
4SC-201 (Resminostat) in Advanced Colorectal Carcinoma
Germany