PT0511 (Not yet branded)

Other Medications

US Experimental Oral 1 Clinical Trials
KRAS

Description

PT0511 is a small molecule compound designed to target KRAS-mutated colorectal cancers. This agent is being developed specifically for patients with KRAS mutations or amplifications, which are present in approximately 40-50% of colorectal cancer cases. PT0511 represents a direct approach to targeting the historically "undruggable" KRAS protein in solid tumors including CRC.

Mechanism of Action

PT0511 appears to function as a KRAS inhibitor, though the specific mechanism of KRAS targeting has not been fully disclosed in available clinical data. The compound is designed to interfere with KRAS signaling pathways that drive tumor cell proliferation and survival in cancers harboring KRAS mutations or amplifications.

Molecular Targets

Side Effects

Fatigue Nausea Diarrhea Decreased appetite Skin rash Elevated liver enzymes Electrolyte imbalances Gastrointestinal toxicity

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT07300150 Phase 1
Recruiting
A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors
United States, South Korea