Description
Pemazyre is approved for the treatment of cholangiocarcinoma with specific genetic alterations but has not been studied extensively in colorectal cancer. It is used as a targeted therapy and its efficacy and safety profile are well established in biliary tract cancers, but it is investigational or off-label in other contexts.
Mechanism of Action
Pemigatanib is a selective and potent inhibitor of FGFR1-3 kinases, which are often mutated or amplified in various cancers including cholangiocarcinoma but not typically colorectal cancer.
Side Effects
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.