Naproxen (Naprosyn, Aleve, Anaprox)
Other Medications · Approved since 1976
Description
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the propionic acid class. In colorectal cancer, naproxen is used as a chemopreventive agent, particularly in patients with Lynch syndrome who have hereditary predisposition to developing colorectal cancer. The drug aims to reduce inflammation and prevent the development of DNA mismatch repair deficient colorectal tumors in high-risk individuals.
Mechanism of Action
Naproxen works by inhibiting cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which are responsible for prostaglandin synthesis. By blocking prostaglandin production, naproxen reduces chronic inflammation in the colorectal mucosa, which may help prevent the progression from normal epithelium to malignant transformation in genetically susceptible patients.
Molecular Targets
Side Effects
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
Quick Info
| Brand Name | Naprosyn, Aleve, Anaprox |
| Category | Other Medications |
 Status | Off-label |
| Administration | Oral |
| Year Approved | 1976 |
| Clinical Trials | 2 |
Related Medications
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.