Krn330 (Not yet branded)

Other Medications

US Experimental EU Experimental ES med_spain_not_available IV 2 Clinical Trials
Unknown specific target

Description

KRN330 is a monoclonal antibody developed for the treatment of metastatic colorectal cancer. This therapeutic antibody has been evaluated both as monotherapy and in combination with irinotecan chemotherapy in patients with advanced colorectal cancer. The drug represents a targeted approach to colorectal cancer treatment, though specific details about its molecular target have not been publicly disclosed in available clinical documentation.

Mechanism of Action

KRN330 functions as a monoclonal antibody that binds to specific antigens expressed on colorectal cancer cells or within the tumor microenvironment. The precise molecular target and downstream signaling pathways affected by KRN330 binding have not been fully characterized in publicly available sources. As a monoclonal antibody, it likely works through mechanisms such as antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, or direct inhibition of growth signaling pathways.

Molecular Targets

Side Effects

Infusion-related reactions Fatigue Nausea Diarrhea Decreased appetite Skin rash Peripheral neuropathy Neutropenia

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT00838578 med_phase_prefix1
Archived
Phase I/II Study of KRN330 Plus Irinotecan in Patients With Metastatic Colorectal Cancer
United States
NCT00575562 med_phase_prefix1
Archived
Phase I Study of KRN330 Monoclonal Antibody in Patients With Colorectal Cancer
United States