GSK5764227 (Not yet branded)

Other Medications

Experimental

med_spain_not_available Not specified in available data 3 Clinical Trials

Not publicly disclosed

Description

GSK5764227 is an early-stage compound being developed by GlaxoSmithKline for advanced solid tumors, including gastrointestinal cancers such as colorectal cancer. Based on clinical trial data, this agent is being tested both as monotherapy and in combination with standard-of-care treatments in patients with advanced malignancies. The drug has progressed through first-in-human Phase 1 studies focusing on safety and preliminary efficacy in heavily pretreated cancer patients.

Mechanism of Action

The specific molecular mechanism of action for GSK5764227 has not been publicly disclosed in available clinical trial documentation. As an early-phase compound, detailed mechanistic information is typically proprietary during initial development phases. The drug appears to target pathways relevant to solid tumor growth based on its inclusion in gastrointestinal cancer protocols.

Molecular Targets

Not publicly disclosed

Side Effects

Specific side effect profile not yet established in public documentation Fatigue Nausea Decreased appetite Diarrhea Elevated liver enzymes Rash Headache

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT07277270 med_phase_prefix1

Recruiting

A Study of GSK5764227 in Combination With Standard of Care (SoC) or Other Agents in Participants With Advanced Solid Tumors

United States, Australia, Spain

NCT06885034 med_phase_prefix1

Recruiting

A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed

United States, Australia, Belgium, Brazil, Canada, France, Italy, Japan, Netherl

NCT05277051 med_phase_prefix1

Active, not recruiting

First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors

United States, Australia, Canada, China, France, Japan, South Korea, Spain, Unit

Quick Info

Brand Name	Not yet branded
Category	Other Medications
Status	Experimental
Estado EMA	Experimental
Acceso España	med_spain_not_available
Administration	Not specified in available data
Clinical Trials	3

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Medical Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.