Ensartinib

Targeted Therapy

Description

Ensartinib is a targeted therapy currently being studied in clinical trials for certain types of cancer, including colorectal cancer. It is being investigated in early-phase trials (Phase 1 and Phase 2) to see if it is safe and effective. These trials are looking at patients whose tumors have specific genetic changes (mutations) like ALK, ATM, BRAF, BRCA1, BRCA2, or EGFR (T790M). It is often studied in combination with other targeted therapies. The goal is to see if ensartinib can help control or shrink tumors in patients with these specific genetic alterations.

Mechanism of Action

Ensartinib is designed to target specific proteins within cancer cells that are involved in tumor growth and survival. The specific molecular target of ensartinib is being characterized in clinical trials. It is believed to interfere with signaling pathways that cancer cells rely on, potentially slowing down their growth or causing them to die. It is being studied in patients whose tumors have specific genetic mutations that might make them sensitive to this type of targeted therapy.

Side Effects

Ensartinib is currently being studied in clinical trials And its side effects are still being evaluated. As with many targeted therapies Potential side effects could include fatigue Nausea Diarrhea Skin reactions And other effects related to the specific proteins it targets. The full range and severity of side effects are still being determined in ongoing research.

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT07448116 Phase 1
Recruiting
Study of MCLA-129 in Combination With Ensartinib in Patients With Advanced Solid Tumors.
China
NCT03155620 Phase 2
Active, not recruiting
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)
United States, Australia, Canada, Puerto Rico