Dsp107 (Not yet branded)

Other Medications

US Experimental EU Experimental ES med_spain_not_available IV 2 Clinical Trials
Unknown specific target

Description

DSP107 is a novel therapeutic compound being developed for advanced colorectal cancer treatment, particularly in combination with the PD-L1 inhibitor atezolizumab. This agent has shown activity across multiple solid tumor types and is being evaluated as an alternative to established anti-angiogenic therapies like fruquintinib. DSP107 appears to target tumors regardless of specific biomarker status, including those with KRAS, BRAF, HER2, EGFR, NTRK, and RET mutations.

Mechanism of Action

DSP107's exact molecular mechanism has not been fully disclosed, but based on its clinical development pattern and combination with immunotherapy agents, it likely modulates immune response pathways or targets angiogenesis. The drug appears to work synergistically with PD-L1 inhibition to enhance anti-tumor immune responses in microsatellite stable colorectal cancers.

Molecular Targets

Side Effects

Fatigue Nausea Decreased appetite Diarrhea Skin rash Elevated liver enzymes Low white blood cell count Infusion reactions

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT07235293 med_phase_prefix2
Recruiting
A Study to Test DSP107 in Combination With Atezolizumab in Comparison With Fruquintinib as a New Treatment for Colorectal Cancer.
United States, Australia
NCT04440735 med_phase_prefix1
Active, not recruiting
A Study of DSP107 Alone and in Combination with Atezolizumab for Patients with Advanced Solid Tumors
United States