Aspirin (Bayer Aspirin, Bufferin, Ecotrin)
Other Medications
Description
Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that functions as a non-selective cyclooxygenase inhibitor, commonly used in colorectal cancer as an adjuvant therapy and for cancer prevention. In CRC treatment, aspirin is primarily utilized for its anti-inflammatory and antiplatelet effects, which may help reduce tumor progression and metastasis. Clinical evidence suggests particular benefit in patients with PIK3CA-mutated colorectal tumors, where aspirin may improve survival outcomes when used alongside standard therapies.
Mechanism of Action
Aspirin irreversibly inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes by acetylating serine residues, thereby blocking the conversion of arachidonic acid to prostaglandins and thromboxane A2. This inhibition reduces inflammation, platelet aggregation, and prostaglandin E2 production, which can promote tumor growth and angiogenesis. The anti-cancer effects are thought to involve modulation of the PI3K/AKT pathway, particularly in PIK3CA-mutated tumors.
Molecular Targets
Side Effects
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
Quick Info
| Brand Name | Bayer Aspirin, Bufferin, Ecotrin |
| Category | Other Medications |
 Status | FDA Approved |
 EMA Status | EMA Approved |
 Spain Access | Funded by SNS other indication |
| Administration | Oral |
| Clinical Trials | 28 |
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Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.