Prednisone
Clinical Trials Overview
2 trials found
About Prednisone
Prednisone is a synthetic corticosteroid medication used in colorectal cancer treatment primarily as supportive care to manage immune-related adverse events, particularly severe colitis caused by immune checkpoint inhibitors. It serves as an anti-inflammatory and immunosuppressive agent to control treatment-related complications rather than directly treating the cancer itself. Prednisone may also be used as premedication to prevent allergic reactions to certain chemotherapy agents or to manage other inflammatory conditions that arise during cancer treatment.
Category
Other Medications
Brand Name
Deltasone, Rayos, Prednisone Intensol
Mechanism
Prednisone acts as a glucocorticoid receptor agonist, binding to cytoplasmic glucocorticoid receptors and forming complexes that translocate to the nucleus to regulate gene transcription. This mechanism suppresses inflammatory cytokine production, reduces T-cell activation, and decreases immune system activity, making it effective for treating immune checkpoint inhibitor-induced colitis and other inflammatory complications of cancer therapy.
2
Total Trials
1
Recruiting
1
Active
0
Completed
842
Total Enrollment
1
Countries
med_trials_active_sites
Recruiting sites
1 countries
Phase:
NCT03819296
Phase 1
Recruiting
800 patients
This trial studies the role of the gut microbiome and effectiveness of a fecal transplant on medication-induced gastrointestinal (GI) complications in patients with melanoma or genitourinary cancer. The gut microbiome (the bacteria and microorganisms...
United States
NCT04305145
Phase 2
Active
42 patients
The goal of this clinical trial is to compare the safety and effectiveness of infliximab compared to steroids for the treatment of immune checkpoint inhibitor-induced colitis (ICI colitis) in patients with stage III/IV skin cancer.
The main question...
United States