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NCT05610163

Evaluación de la adición de un fármaco antitumoral, el irinotecán, al tratamiento de quimioterapia estándar (FOLFOX) tras la radioterapia prolongada en pacientes con cáncer de recto en estadio avanzado, con el fin de mejorar la tasa de respuesta completa y las tasas a largo plazo de preservación de órganos.

Activo, No Reclutando Fase 2

Descripción

Este ensayo de fase II compara el efecto de irinotecán frente a oxaliplatino tras quimiorradiación prolongada en pacientes con cáncer de recto en estadio II-III. Los fármacos de quimioterapia combinada, como FOLFIRINOX (fluorouracilo, irinotecán, leucovorina y oxaliplatino), FOLFOX (leucovorina, fluorouracilo, oxaliplatino e irinotecán) y CAPOX (capecitabina y oxaliplatino), actúan de diferentes maneras para detener el crecimiento de las células tumorales, ya sea matando las células, impidiendo que se dividan o impidiendo que se propaguen. FOLFOX o CAPOX se utilizan tras la quimiorradiación como tratamiento habitual para el cáncer de recto. La administración de FOLFIRINOX tras la quimiorradiación puede aumentar la tasa de respuesta y dar lugar a tasas más altas de respuesta clínica completa (con la posibilidad de evitar la cirugía) en comparación con FOLFOX o CAPOX tras la quimiorradiación en pacientes con cáncer de recto localmente avanzado.

Evidencia de la diana molecular en cáncer colorrectal

Aún no hay evidencia documentada en nuestra base para la diana o el fármaco de este ensayo. Esta sección crece a medida que se procesan nuevas publicaciones.

Criterios de Elegibilidad

Criterios de inclusión:

  • Estadio: Adenocarcinoma rectal en estadio clínico II o III, definido como T4N0 o cualquier T con enfermedad de ganglios positivos (cualquier T, N+); también T3N0 que requiera resección abdominoperineal (APR) o coloanastomosis.
  • Localización del tumor: Recto; ≤ 12 cm desde el borde anal.
  • No se permite quimioterapia sistémica, terapia dirigida o inmunoterapia previa; o radioterapia administrada como tratamiento para el cáncer colorrectal en los últimos 5 años.
  • No estar embarazada ni en período de lactancia, ya que este estudio implica un agente que tiene efectos genotóxicos, mutagénicos y teratogénicos conocidos.
  • Por lo tanto, solo en mujeres con potencial de fertilidad, se requiere una prueba de embarazo negativa (orina o suero, según las pautas institucionales) realizada ≤ 14 días antes del registro. Las participantes femeninas aceptan utilizar métodos anticonceptivos altamente eficaces combinados con un método de barrera adicional (por ejemplo, diafragma, con espermicida) durante el estudio y durante ≥ 9 meses después de la última dosis del fármaco del estudio, y los mismos criterios son aplicables a los participantes masculinos si tienen una pareja con potencial de fertilidad. El participante masculino acepta utilizar un preservativo y no donar esperma mientras participe en este estudio y durante ≥ 6 meses después del último tratamiento.
  • Edad ≥ 18 años.
  • Estado funcional del Grupo de Oncología Cooperativa del Este (ECOG) ≤ 2 (o Karnofsky ≥ 60 %).
  • Recuento absoluto de neutrófilos (ANC) ≥ 1.500/mm³.
  • Recuento de plaquetas ≥ 100.000/mm³.
  • Creatinina ≤ 1,5 veces el límite superior de la normalidad (ULN) O aclaramiento de creatinina calculado (calc.) ≥ 50 ml/min.
  • Bilirrubina total ≤ 1,5 veces el límite superior de la normalidad (ULN).
  • Aspartato aminotransferasa (AST)/alanina aminotransferasa (ALT) ≤ 3 veces el límite superior de la normalidad (ULN).
  • No tener tumores rectales superiores (margen distal del tumor > 12 cm desde el borde anal).
  • No tener cáncer rectal recurrente; resección transanal previa, cáncer de sigma distal previo con una anastomosis baja.
  • No tener adenocarcinoma rectal con deficiencia conocida en la reparación de errores de emparejamiento.
  • Los pacientes infectados por el virus de la inmunodeficiencia humana (VIH) que estén recibiendo terapia antirretroviral eficaz con carga viral indetectable en los últimos 6 meses son elegibles para este ensayo.
  • Los pacientes con antecedentes conocidos o síntomas actuales de enfermedad cardíaca, o con antecedentes de tratamiento con agentes cardiotóxicos, deben someterse a una evaluación del riesgo clínico de la función cardíaca utilizando la clasificación funcional de la Asociación Cardíaca de Nueva York1. Para ser elegibles para este ensayo, los pacientes deben estar en la clase 2B o superior.
  • No se permite el tratamiento concomitante crónico con inhibidores potentes de CYP3A4 en este estudio. Los pacientes que estén tomando inhibidores potentes de CYP3A4 deben suspender el fármaco 14 días antes del registro en el estudio.
  • No se permite el tratamiento concomitante crónico con inductores potentes de CYP3A4. Los pacientes deben suspender el fármaco 14 días antes del inicio del tratamiento del estudio.

Información del Ensayo

NCT05610163
Activo, No Reclutando
Fase 2
783 participantes
Dic 2022
Sep 2026

Ubicaciones685

Puerto Rico (6)
Cancer Center-Metro Medical Center Bayamon
Bayamón
Doctors Cancer Center
Manati
Centro Comprensivo de Cancer de UPR
San Juan
Pan American Center for Oncology Trials LLC
San Juan
San Juan City Hospital
San Juan
San Juan Community Oncology Group
San Juan
United States (679)
Hawaii Cancer Care - Westridge
‘Aiea
Pali Momi Medical Center
‘Aiea
Queen's Cancer Center - Pearlridge
‘Aiea
The Cancer Center of Hawaii-Pali Momi
‘Aiea
The Queen's Medical Center - West Oahu
‘Ewa Beach
Avera Cancer Institute-Aberdeen
Aberdeen
Providence Regional Cancer System-Aberdeen
Aberdeen
Atrium Health Stanly/LCI-Albemarle
Albemarle
University of New Mexico Cancer Center
Albuquerque
Lehigh Valley Hospital-Cedar Crest
Allentown
AdventHealth Altamonte
Altamonte Springs
OSF Saint Anthony's Health Center
Alton
UPMC Altoona
Altoona
The Don and Sybil Harrington Cancer Center
Amarillo
Alaska Breast Care and Surgery LLC
Anchorage
Alaska Oncology and Hematology LLC
Anchorage
Alaska Women's Cancer Care
Anchorage
Anchorage Associates in Radiation Medicine
Anchorage
Anchorage Oncology Centre
Anchorage
Katmai Oncology Group
Anchorage
Providence Alaska Medical Center
Anchorage
AnMed Health Cancer Center
Anderson
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor
University of Michigan Comprehensive Cancer Center
Ann Arbor
Langlade Hospital and Cancer Center
Antigo
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande
PCR Oncology
Arroyo Grande
Duluth Clinic Ashland
Ashland
Northwest Wisconsin Cancer Center
Ashland
Emory Saint Joseph's Hospital
Atlanta
Emory University Hospital Midtown
Atlanta
Emory University Hospital/Winship Cancer Institute
Atlanta
Advocate Outpatient Center - Aurora
Aurora
Rush-Copley Medical Center
Aurora
UCHealth University of Colorado Hospital
Aurora
Mount Sinai Comprehensive Cancer Center at Aventura
Aventura
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Baltimore
MedStar Good Samaritan Hospital
Baltimore
Sinai Hospital of Baltimore
Baltimore
Advocate Good Shepherd Hospital
Barrington
Memorial Sloan Kettering Basking Ridge
Basking Ridge
UPMC-Heritage Valley Health System Beaver
Beaver
Indu and Raj Soin Medical Center
Beavercreek
PeaceHealth Saint Joseph Medical Center
Bellingham
Sanford Joe Lueken Cancer Center
Bemidji
Saint Charles Health System
Bend
Central Vermont Medical Center/National Life Cancer Treatment
Berlin Corners
Lehigh Valley Hospital - Muhlenberg
Bethlehem
Billings Clinic Cancer Center
Billings
University of Alabama at Birmingham Cancer Center
Birmingham
Sanford Bismarck Medical Center
Bismarck
Illinois CancerCare-Bloomington
Bloomington
OSF Saint Joseph Medical Center
Bloomington
Saint Elizabeth Boardman Hospital
Boardman
Saint Alphonsus Cancer Care Center-Boise
Boise
Saint Luke's Cancer Institute - Boise
Boise
Central Care Cancer Center - Bolivar
Bolivar
Beth Israel Deaconess Medical Center
Boston
Boston Medical Center
Boston
Dana-Farber Cancer Institute
Boston
Bozeman Health Deaconess Hospital
Bozeman
Essentia Health Saint Joseph's Medical Center
Brainerd
Lafayette Family Cancer Center-EMMC
Brewer
United Hospital Center
Bridgeport
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton
Trinity Health Medical Center - Brighton
Brighton
University of Michigan - Brighton Center for Specialty Care
Brighton
New York-Presbyterian/Brooklyn Methodist Hospital
Brooklyn
NYU Langone Hospital - Brooklyn
Brooklyn
Henry Ford Cancer Institute-Downriver
Brownstown
Keck Medicine of USC Buena Park
Buena Park
Roswell Park Cancer Institute
Buffalo
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank
Aurora Cancer Care-Southern Lakes VLCC
Burlington
Lahey Hospital and Medical Center
Burlington
University of Vermont and State Agricultural College
Burlington
University of Vermont Medical Center
Burlington
Minnesota Oncology - Burnsville
Burnsville
Saint James Community Hospital and Cancer Treatment Center
Butte
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell
Cooper Hospital University Medical Center
Camden
UPMC Camp Hill
Camp Hill
Aultman Health Foundation
Canton
Illinois CancerCare-Canton
Canton
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton
Trinity Health Medical Center - Canton
Canton
Mercy Cancer Center - Cape Girardeau
Cape Girardeau
Saint Francis Medical Center
Cape Girardeau
Memorial Hospital of Carbondale
Carbondale
Carlisle Regional Cancer Center
Carlisle
Mercy Cancer Center - Carmichael
Carmichael
Mercy San Juan Medical Center
Carmichael
Caro Cancer Center
Caro
SIH Cancer Institute
Carterville
Illinois CancerCare-Carthage
Carthage
Duke Cancer Center Cary
Cary
Mercy Hospital
Cedar Rapids
Oncology Associates at Mercy Medical Center
Cedar Rapids
AdventHealth Celebration
Celebration
Dayton Physicians LLC-Miami Valley South
Centerville
Centralia Oncology Clinic
Centralia
Providence Regional Cancer System-Centralia
Centralia
Saint Mary's Hospital
Centralia
Christiana Care Health System-Concord Health Center
Chadds Ford
UNC Lineberger Comprehensive Cancer Center
Chapel Hill
Medical University of South Carolina
Charleston
Atrium Health Pineville/LCI-Pineville
Charlotte
Atrium Health University City/LCI-University
Charlotte
Carolinas Medical Center/Levine Cancer Institute
Charlotte
Levine Cancer Institute-Ballantyne
Charlotte
Levine Cancer Institute-SouthPark
Charlotte
University of Virginia Cancer Center
Charlottesville
Chelsea Hospital
Chelsea
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea
Jefferson Cherry Hill Hospital
Cherry Hill
Advocate Illinois Masonic Medical Center
Chicago
John H Stroger Jr Hospital of Cook County
Chicago
Northwestern University
Chicago
University of Chicago Comprehensive Cancer Center
Chicago
Bethesda North Hospital
Cincinnati
Good Samaritan Hospital - Cincinnati
Cincinnati
Oncology Hematology Care Inc-Kenwood
Cincinnati
Clackamas Radiation Oncology Center
Clackamas
Providence Cancer Institute Clackamas Clinic
Clackamas
Morton Plant Hospital
Clearwater
Wake Forest University at Clemmons
Clemmons
MetroHealth Medical Center
Cleveland
Henry Ford Macomb Hospital-Clinton Township
Clinton Township
Mercy Cancer Center-West Lakes
Clive
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive
Kootenai Health - Coeur d'Alene
Coeur d'Alene
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville
Memorial Hospital North
Colorado Springs
Penrose-Saint Francis Healthcare
Colorado Springs
Rocky Mountain Cancer Centers-Penrose
Colorado Springs
Saint Francis Cancer Center
Colorado Springs
UCHealth Memorial Hospital Central
Colorado Springs
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus
Ohio State University Comprehensive Cancer Center
Columbus
Memorial Sloan Kettering Commack
Commack
Atrium Health Cabarrus/LCI-Concord
Concord
New Hampshire Oncology Hematology PA-Concord
Concord
MD Anderson in The Woodlands
Conroe
Mercy Hospital
Coon Rapids
Bay Area Hospital
Coos Bay
Baptist Health Corbin
Corbin
Ochsner Hematology Oncology North Shore - Covington (West Region)
Covington
Greater Regional Medical Center
Creston
Northwest Cancer Center - Main Campus
Crown Point
AMG Crystal Lake - Oncology
Crystal Lake
UPMC Western Maryland
Cumberland
Parkland Memorial Hospital
Dallas
UT Southwestern Simmons Cancer Center - RedBird
Dallas
UT Southwestern/Simmons Cancer Center-Dallas
Dallas
Carle at The Riverfront
Danville
Dayton Physician LLC - Englewood
Dayton
Corewell Health Dearborn Hospital
Dearborn
Cancer Care Specialists of Illinois - Decatur
Decatur
Decatur Memorial Hospital
Decatur
Emory Decatur Hospital
Decatur
Essentia Health - Deer River Clinic
Deer River
Northwestern Medicine Cancer Center Kishwaukee
DeKalb
AdventHealth Porter
Denver
Saint Joseph Hospital - Cancer Centers of Colorado
Denver
UCHealth - Cherry Creek
Denver
Iowa Methodist Medical Center
Des Moines
Mercy Medical Center - Des Moines
Des Moines
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines
Henry Ford Health Saint John Hospital
Detroit
Henry Ford Hospital
Detroit
Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes
Illinois CancerCare-Dixon
Dixon
Advocate Good Samaritan Hospital
Downers Grove
City of Hope Comprehensive Cancer Center
Duarte
Essentia Health Cancer Center
Duluth
Essentia Health Saint Mary's Medical Center
Duluth
Miller-Dwan Hospital
Duluth
Duke University Medical Center
Durham
Northwest Oncology LLC
Dyer
Pocono Medical Center
East Stroudsburg
Marshfield Medical Center-EC Cancer Center
Eau Claire
Saint Elizabeth Healthcare Edgewood
Edgewood
Fairview Southdale Hospital
Edina
Swedish Cancer Institute-Edmonds
Edmonds
Carle Physician Group-Effingham
Effingham
Crossroads Cancer Center
Effingham
Advocate Sherman Hospital
Elgin
Mercy Cancer Center - Elk Grove
Elk Grove
Elmhurst Memorial Hospital
Elmhurst
Saint Vincent Hospital
Erie
UPMC Hillman Cancer Center Erie
Erie
Illinois CancerCare-Eureka
Eureka
Providence Regional Cancer Partnership
Everett
Inova Fair Oaks Hospital
Fairfax
Inova Schar Cancer Institute
Fairfax
Inova Fairfax Hospital
Falls Church
Essentia Health Cancer Center-South University Clinic
Fargo
Sanford Broadway Medical Center
Fargo
Sanford Roger Maris Cancer Center
Fargo
Farmington Health Center
Farmington
Parkland Health Center - Farmington
Farmington
Corewell Health Farmington Hills Hospital
Farmington Hills
UPMC Cancer Center at UPMC Horizon
Farrell
Armes Family Cancer Center
Findlay
Blanchard Valley Hospital
Findlay
Orion Cancer Care
Findlay
Genesys Hurley Cancer Institute
Flint
Hurley Medical Center
Flint
The New York Hospital Medical Center of Queens
Flushing
Levine Cancer Institute - Rutherford
Forest City
Northwell Health Physicians Partners Radiation Medicine at Queens
Forest Hills
Holy Cross Hospital
Fort Lauderdale
Mercy Hospital Fort Smith
Fort Smith
Saint Elizabeth Healthcare Fort Thomas
Fort Thomas
Parkview Regional Medical Center
Fort Wayne
Tarrant County Hospital District/JPS Health Network
Fort Worth
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth
Essentia Health - Fosston
Fosston
Dana-Farber Cancer Institute at Foxborough
Foxborough
Dayton Physicians LLC-Atrium
Franklin
Washington Hospital
Fremont
Saint Luke's Cancer Institute - Fruitland
Fruitland
Gibbs Cancer Center-Gaffney
Gaffney
University of Florida Health Science Center - Gainesville
Gainesville
Illinois CancerCare-Galesburg
Galesburg
Western Illinois Cancer Treatment Center
Galesburg
Central Care Cancer Center - Garden City
Garden City
Levine Cancer Institute-Gaston
Gastonia
Northwestern Medicine Cancer Center Delnor
Geneva
Tidelands Georgetown Memorial Hospital
Georgetown
Aurora Health Care Germantown Health Center
Germantown
The West Clinic - Wolf River
Germantown
Glens Falls Hospital
Glens Falls
Northwestern Medicine Glenview Outpatient Center
Glenview
Lutheran Hospital - Cancer Centers of Colorado
Golden
Aurora Cancer Care-Grafton
Grafton
Saint Mary's Hospital and Regional Medical Center
Grand Junction
Northwestern Medicine Grayslake Outpatient Center
Grayslake
Central Care Cancer Center - Great Bend
Great Bend
Benefis Sletten Cancer Institute
Great Falls
Great Falls Clinic
Great Falls
Aurora BayCare Medical Center
Green Bay
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay
Saint Vincent Hospital Cancer Center Green Bay
Green Bay
Northwell Health Cancer Institute at Huntington
Greenlawn
UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg
Dayton Physicians LLC-Wayne
Greenville
East Carolina University
Greenville
Prisma Health Cancer Institute - Eastside
Greenville
Prisma Health Cancer Institute - Faris
Greenville
UPMC Hillman Cancer Center in Greenville/UPMC Horizon
Greenville
Wayne Hospital
Greenville
Gibbs Cancer Center-Pelham
Greer
Prisma Health Cancer Institute - Greer
Greer
Baptist Cancer Center-Grenada
Grenada
Legacy Mount Hood Medical Center
Gresham
Henry Ford Saint John Hospital - Van Elslander
Grosse Pointe Woods
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg
Memorial Sloan Kettering Westchester
Harrison
Hartford Hospital
Hartford
Ingalls Memorial Hospital
Harvey
Hi-Line Sletten Cancer Center
Havre
Essentia Health-Hayward Clinic
Hayward
Advocate South Suburban Hospital
Hazel Crest
Comprehensive Cancer Centers of Nevada - Henderson
Henderson
OptumCare Cancer Care at Seven Hills
Henderson
Penn State Milton S Hershey Medical Center
Hershey
Essentia Health Hibbing Clinic
Hibbing
Hayworth Cancer Center
High Point
UCHealth Highlands Ranch Hospital
Highlands Ranch
University of North Carolina-Hillsborough Campus
Hillsborough
Northwest Cancer Center - Hobart
Hobart
Saint Mary Medical Center
Hobart
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu
Kapiolani Medical Center for Women and Children
Honolulu
Kuakini Medical Center
Honolulu
Queen's Cancer Cenrer - POB I
Honolulu
Queen's Cancer Center - Kuakini
Honolulu
Queen's Medical Center
Honolulu
Straub Clinic and Hospital
Honolulu
The Cancer Center of Hawaii-Liliha
Honolulu
University of Hawaii Cancer Center
Honolulu
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston
Ben Taub General Hospital
Houston
Lyndon Baines Johnson General Hospital
Houston
M D Anderson Cancer Center
Houston
MD Anderson West Houston
Houston
IRMC Cancer Center
Indiana
City of Hope at Irvine Lennar
Irvine
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine
Swedish Cancer Institute-Issaquah
Issaquah
Allegiance Health
Jackson
Mayo Clinic in Florida
Jacksonville
Essentia Health - Jamestown Clinic
Jamestown
MU Health Care Goldschmidt Cancer Center
Jefferson City
Jefferson Hospital
Jefferson Hills
Emory Johns Creek Hospital
Johns Creek
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro
Freeman Health System
Joplin
Mercy Hospital Joplin
Joplin
Castle Medical Center
Kailua
Logan Health Medical Center
Kalispell
CHI Health Good Samaritan
Kearney
Kadlec Clinic Hematology and Oncology
Kennewick
Aurora Cancer Care-Kenosha South
Kenosha
Greater Dayton Cancer Center
Kettering
Kettering Medical Center
Kettering
Illinois CancerCare-Kewanee Clinic
Kewanee
Kingman Regional Medical Center
Kingman
FHCC at EvergreenHealth
Kirkland
AdventHealth Kissimmee
Kissimmee
Providence Regional Cancer System-Lacey
Lacey
Northwestern Medicine Lake Forest Hospital
Lake Forest
Northwell Health/Center for Advanced Medicine
Lake Success
Saint Anthony Hospital
Lakewood
University of Michigan Health - Sparrow Lansing
Lansing
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas
Comprehensive Cancer Centers of Nevada
Las Vegas
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas
Comprehensive Cancer Centers of Nevada - Town Center
Las Vegas
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas
GenesisCare USA - Fort Apache
Las Vegas
GenesisCare USA - Las Vegas
Las Vegas
OptumCare Cancer Care at Charleston
Las Vegas
OptumCare Cancer Care at Fort Apache
Las Vegas
OptumCare Cancer Care at MountainView
Las Vegas
Radiation Oncology Centers of Nevada Central
Las Vegas
Radiation Oncology Centers of Nevada Southeast
Las Vegas
Summerlin Hospital Medical Center
Las Vegas
MD Anderson League City
League City
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon
Inova Loudoun Hospital
Leesburg
Beebe Medical Center
Lewes
Baptist Health Hamburg
Lexington
Baptist Health Lexington
Lexington
Saint Joseph Hospital
Lexington
Saint Joseph Hospital East
Lexington
Saint Joseph Radiation Oncology Resource Center
Lexington
University of Kentucky/Markey Cancer Center
Lexington
AMG Libertyville - Oncology
Libertyville
Condell Memorial Hospital
Libertyville
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue
Atrium Health Lincoln/LCI-Lincolnton
Lincolnton
University of Arkansas for Medical Sciences
Little Rock
AdventHealth Littleton
Littleton
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia
The Dana-Farber Cancer Institute at Londonderry
Londonderry
Longmont United Hospital
Longmont
PeaceHealth Saint John Medical Center
Longview
Los Angeles General Medical Center
Los Angeles
USC / Norris Comprehensive Cancer Center
Los Angeles
Baptist Health Louisville
Louisville
The James Graham Brown Cancer Center at University of Louisville
Louisville
UofL Health Medical Center Northeast
Louisville
Saint Joseph's Hospital-North
Lutz
Henry Ford Saint John Hospital - Macomb Medical
Macomb
Illinois CancerCare-Macomb
Macomb
Solinsky Center for Cancer Care
Manchester
North Shore University Hospital
Manhasset
Fairview Clinics and Surgery Center Maple Grove
Maple Grove
Minnesota Oncology Hematology PA-Maplewood
Maplewood
Saint John's Hospital - Healtheast
Maplewood
Aurora Bay Area Medical Group-Marinette
Marinette
Saint Mary's Oncology/Hematology Associates of Marlette
Marlette
Marshfield Medical Center-Marshfield
Marshfield
Sovah Health Martinsville
Martinsville
Levine Cancer Institute - Union West
Matthews
Carle Physician Group-Mattoon/Charleston
Mattoon
UPMC Cancer Center at UPMC McKeesport
McKeesport
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg
Aspirus Medford Hospital
Medford
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis
Froedtert Menomonee Falls Hospital
Menomonee Falls
Mercy Cancer Center
Merced
Midstate Medical Center
Meriden
Idaho Urologic Institute-Meridian
Meridian
Saint Luke's Cancer Institute - Meridian
Meridian
Dana Farber-Merrimack Valley
Methuen
Mount Sinai Medical Center
Miami Beach
Garnet Health Medical Center
Middletown
Memorial Sloan Kettering Monmouth
Middletown
MyMichigan Medical Center Midland
Midland
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
Milford
Beebe South Coastal Health Campus
Millville
Aurora Cancer Care-Milwaukee
Milwaukee
Aurora Saint Luke's Medical Center
Milwaukee
Aurora Sinai Medical Center
Milwaukee
Medical College of Wisconsin
Milwaukee
NYU Langone Hospital - Long Island
Mineola
Abbott-Northwestern Hospital
Minneapolis
Health Partners Inc
Minneapolis
Hennepin County Medical Center
Minneapolis
Marshfield Medical Center - Minocqua
Minocqua
Community Medical Center
Missoula
Saint Patrick Hospital - Community Hospital
Missoula
Avera Cancer Institute - Mitchell
Mitchell
University of South Alabama Mitchell Cancer Institute
Mobile
Atrium Health Union/LCI-Union
Monroe
Forbes Hospital
Monroeville
UPMC Cancer Center - Monroeville
Monroeville
UPMC Hillman Cancer Center - Monroeville
Monroeville
Monticello Cancer Center
Monticello
Memorial Sloan Kettering Bergen
Montvale
UPMC Hillman Cancer Center in Coraopolis
Moon Township
West Virginia University Healthcare
Morgantown
Morristown Medical Center
Morristown
Northern Westchester Hospital
Mount Kisco
UPMC Hillman Cancer Center - Part of Frick Hospital
Mount Pleasant
Skagit Regional Health Cancer Care Center
Mount Vernon
SSM Health Good Samaritan
Mount Vernon
ProHealth D N Greenwald Center
Mukwonago
The Community Hospital
Munster
Women's Diagnostic Center - Munster
Munster
MUSC Health Tidelands Health Radiation Therapy Center
Murrells Inlet
Arnold Palmer Cancer Center Medical Oncology Norwin
N. Huntingdon
Saint Alphonsus Cancer Care Center-Nampa
Nampa
Saint Luke's Cancer Institute - Nampa
Nampa
Providence Queen of The Valley
Napa
Edward Hospital/Cancer Center
Naperville
Vanderbilt Breast Center at One Hundred Oaks
Nashville
Vanderbilt University/Ingram Cancer Center
Nashville
UPMC Cancer Center-Natrona Heights
Natrona Heights
Baptist Health Floyd
New Albany
Baptist Memorial Hospital and Cancer Center-Union County
New Albany
The Hospital of Central Connecticut
New Britain
UPMC Hillman Cancer Center - New Castle
New Castle
Long Island Jewish Medical Center
New Hyde Park
UC Comprehensive Cancer Center at Silver Cross
New Lenox
Ochsner Medical Center Jefferson
New Orleans
University Medical Center New Orleans
New Orleans
Cancer Center of Western Wisconsin
New Richmond
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York
Lenox Hill Hospital
New York
Manhattan Eye Ear and Throat Hospital
New York
Memorial Sloan Kettering Cancer Center
New York
Mount Sinai Hospital
New York
Mount Sinai West
New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York
NYP/Weill Cornell Medical Center
New York
Christiana Care Health System-Christiana Hospital
Newark
Delaware Clinical and Laboratory Physicians PA
Newark
Helen F Graham Cancer Center
Newark
Medical Oncology Hematology Consultants PA
Newark
Providence Newberg Medical Center
Newberg
USC Norris Oncology/Hematology-Newport Beach
Newport Beach
Carle BroMenn Medical Center
Normal
Carle Cancer Institute Normal
Normal
Henry Ford Health Providence Novi Hospital
Novi
Henry Ford Medical Center-Columbus
Novi
Cancer Care Center of O'Fallon
O'Fallon
HSHS Saint Elizabeth's Hospital
O'Fallon
Drexel Town Square Health Center
Oak Creek
Advocate Christ Medical Center
Oak Lawn
ProHealth Oconomowoc Memorial Hospital
Oconomowoc
Mercy Hospital Oklahoma City
Oklahoma City
University of Oklahoma Health Sciences Center
Oklahoma City
Alegent Health Bergan Mercy Medical Center
Omaha
Alegent Health Immanuel Medical Center
Omaha
Alegent Health Lakeside Hospital
Omaha
Creighton University Medical Center
Omaha
Saint Joseph Hospital - Orange
Orange
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange
Providence Willamette Falls Medical Center
Oregon City
University of Chicago Medicine-Orland Park
Orland Park
AdventHealth East Orlando
Orlando
AdventHealth Orlando
Orlando
Lake Regional Hospital
Osage Beach
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh
Upstate Cancer Center at Oswego
Oswego
Illinois CancerCare-Ottawa Clinic
Ottawa
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford
Baptist Health Paducah
Paducah
Advocate High Tech Medical Park
Palos Heights
The Valley Hospital - Luckow Pavilion
Paramus
Essentia Health - Park Rapids
Park Rapids
Advocate Lutheran General Hospital
Park Ridge
AdventHealth Parker
Parker
Camden Clark Medical Center
Parkersburg
Lahey Medical Center-Peabody
Peabody
Illinois CancerCare-Pekin
Pekin
Memorial Hospital West
Pembroke Pines
Illinois CancerCare-Peoria
Peoria
Methodist Medical Center of Illinois
Peoria
Illinois CancerCare-Peru
Peru
Valley Radiation Oncology
Peru
Jefferson Torresdale Hospital
Philadelphia
Thomas Jefferson University Hospital
Philadelphia
Cancer Center at Saint Joseph's
Phoenix
Mayo Clinic Hospital in Arizona
Phoenix
Avera Cancer Institute at Pierre
Pierre
Allegheny General Hospital
Pittsburgh
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh
UPMC-Magee Womens Hospital
Pittsburgh
UPMC-Mercy Hospital
Pittsburgh
UPMC-Passavant Hospital
Pittsburgh
UPMC-Saint Clair Hospital Cancer Center
Pittsburgh
UPMC-Saint Margaret
Pittsburgh
UPMC-Shadyside Hospital
Pittsburgh
West Penn Hospital
Pittsburgh
Edward Hospital/Cancer Center?Plainfield
Plainfield
Chilton Medical Center
Pompton
Michigan Healthcare Professionals Pontiac
Pontiac
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac
Legacy Good Samaritan Hospital and Medical Center
Portland
Providence Portland Medical Center
Portland
Providence Saint Vincent Medical Center
Portland
Kootenai Clinic Cancer Services - Post Falls
Post Falls
Illinois CancerCare-Princeton
Princeton
Saint Mary Corwin Medical Center
Pueblo
Aurora Cancer Care-Racine
Racine
Duke Cancer Center Raleigh
Raleigh
Queens Cancer Center
Rego Park
Beebe Health Campus
Rehoboth Beach
Radiation Oncology Associates
Reno
Renown Regional Medical Center
Reno
Saint Mary's Regional Medical Center
Reno
Valley Medical Center
Renton
Aspirus Cancer Care - James Beck Cancer Center
Rhinelander
Marshfield Medical Center-Rice Lake
Rice Lake
UT Southwestern Clinical Center at Richardson/Plano
Richardson
Reid Health
Richmond
VCU Massey Cancer Center at Stony Point
Richmond
VCU Massey Comprehensive Cancer Center
Richmond
Virginia Cancer Institute
Richmond
Valley Health System Ridgewood Campus
Ridgewood
North Memorial Medical Health Center
Robbinsdale
Mayo Clinic in Rochester
Rochester
University of Rochester
Rochester
Levine Cancer Institute-Rock Hill
Rock Hill
Rock Hill Radiation Therapy Center
Rock Hill
Mercy Cancer Center - Rocklin
Rocklin
Mercy Clinic-Rolla-Cancer and Hematology
Rolla
Phelps Health Delbert Day Cancer Institute
Rolla
Scott and White Healthcare Round Rock
Round Rock
Corewell Health William Beaumont University Hospital
Royal Oak
Mercy Cancer Center - Sacramento
Sacramento
University of California Davis Comprehensive Cancer Center
Sacramento
MyMichigan Medical Center Saginaw
Saginaw
Oncology Hematology Associates of Saginaw Valley PC
Saginaw
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud
Heartland Regional Medical Center
Saint Joseph
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park
Regions Hospital
Saint Paul
United Hospital
Saint Paul
Sainte Genevieve County Memorial Hospital
Sainte Genevieve
Salinas Valley Memorial
Salinas
Huntsman Cancer Institute/University of Utah
Salt Lake City
University of Utah Sugarhouse Health Center
Salt Lake City
University of Texas Health Science Center at San Antonio
San Antonio
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo
Essentia Health Sandstone
Sandstone
Mission Hope Medical Oncology - Santa Maria
Santa Maria
Providence Medical Foundation - Santa Rosa
Santa Rosa
Memorial Health University Medical Center
Savannah
Fred Hutchinson Cancer Center
Seattle
Swedish Medical Center-Ballard Campus
Seattle
Swedish Medical Center-First Hill
Seattle
University of Washington Medical Center - Montlake
Seattle
Virginia Mason Medical Center
Seattle
PeaceHealth United General Medical Center
Sedro-Woolley
Prisma Health Cancer Institute - Seneca
Seneca
UPMC Cancer Center at UPMC Northwest
Seneca
Sidney Kimmel Cancer Center Washington Township
Sewell
Saint Francis Regional Medical Center
Shakopee
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan
Atrium Health Cleveland/LCI-Cleveland
Shelby
Welch Cancer Center
Sheridan
Saint Michael Cancer Center
Silverdale
Avera Cancer Institute
Sioux Falls
Sanford Cancer Center Oncology Clinic
Sioux Falls
Sanford USD Medical Center - Sioux Falls
Sioux Falls
Phelps Memorial Hospital Center
Sleepy Hollow
City of Hope South Pasadena
South Pasadena
Dana-Farber/Brigham and Women's Cancer Center at South Shore
South Weymouth
Henry Ford Health Providence Southfield Hospital
Southfield
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven
Spartanburg Medical Center
Spartanburg
Essentia Health-Spooner Clinic
Spooner
CoxHealth South Hospital
Springfield
Mercy Hospital Springfield
Springfield
Southern Illinois University School of Medicine
Springfield
Springfield Clinic
Springfield
Springfield Memorial Hospital
Springfield
Mercy Hospital Saint Louis
St Louis
Mercy Hospital South
St Louis
Missouri Baptist Medical Center
St Louis
Saint Helena Hospital
St. Helena
Saint Anthony's Hospital Cancer Care Center
St. Petersburg
Aspirus Cancer Care - Stevens Point
Stevens Point
Marshfield Medical Center-River Region at Stevens Point
Stevens Point
Lakeview Hospital
Stillwater
Saint Joseph's Medical Center
Stockton
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay
MD Anderson in Sugar Land
Sugar Land
Missouri Baptist Sullivan Hospital
Sullivan
Aurora Medical Center in Summit
Summit
Overlook Hospital
Summit
BJC Outpatient Center at Sunset Hills
Sunset Hills
Essentia Health Saint Mary's Hospital - Superior
Superior
State University of New York Upstate Medical University
Syracuse
SUNY Upstate Medical Center-Community Campus
Syracuse
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa
Tampa General Hospital
Tampa
MyMichigan Medical Center Tawas
Tawas City
Holy Name Hospital
Teaneck
Scott and White Memorial Hospital
Temple
Montefiore Medical Center - Moses Campus
The Bronx
Montefiore Medical Center-Einstein Campus
The Bronx
Montefiore Medical Center-Weiler Hospital
The Bronx
City of Hope South Bay
Torrance
Corewell Health Beaumont Troy Hospital
Troy
Dayton Physicians LLC - Troy
Troy
Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee
Legacy Meridian Park Hospital
Tualatin
Saint Luke's Cancer Institute - Twin Falls
Twin Falls
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers
SMC Center for Hematology Oncology Union
Union
Memorial Sloan Kettering Nassau
Uniondale
UPMC Cancer Center-Uniontown
Uniontown
UPMC Uniontown Hospital Radiation Oncology
Uniontown
City of Hope Upland
Upland
Carle Cancer Center
Urbana
Northwest Cancer Center - Valparaiso
Valparaiso
Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver
Legacy Salmon Creek Hospital
Vancouver
PeaceHealth Southwest Medical Center
Vancouver
Upstate Cancer Center at Verona
Verona
Essentia Health Virginia Clinic
Virginia
Ridgeview Medical Center
Waconia
Providence Saint Mary Regional Cancer Center
Walla Walla
John Muir Medical Center-Walnut Creek
Walnut Creek
Henry Ford Health Warren Hospital
Warren
Saint Joseph Warren Hospital
Warren
Northwestern Medicine Cancer Center Warrenville
Warrenville
Illinois CancerCare - Washington
Washington
UPMC Cancer Center-Washington
Washington
UPMC Washington Hospital Radiation Oncology
Washington
George Washington University Medical Center
Washington D.C.
MedStar Georgetown University Hospital
Washington D.C.
MedStar Washington Hospital Center
Washington D.C.
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee
UW Cancer Center at ProHealth Care
Waukesha
Aspirus Regional Cancer Center
Wausau
Aurora Cancer Care-Milwaukee West
Wauwatosa
Wilmot Cancer Institute at Webster
Webster
Aurora West Allis Medical Center
West Allis
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend
Henry Ford West Bloomfield Hospital
West Bloomfield
Saint Mary's Oncology/Hematology Associates of West Branch
West Branch
Chester County Hospital
West Chester
Lexington Medical Center
West Columbia
Mercy Medical Center-West Lakes
West Des Moines
Reading Hospital
West Reading
Saint Anthony North Hospital
Westminster
William E Kahlert Regional Cancer Center/Sinai Hospital
Westminster
Marshfield Medical Center - Weston
Weston
Valley Health System-Hematology/Oncology
Westwood
Wexford Health and Wellness Pavilion
Wexford
Intermountain Health Lutheran Hospital
Wheat Ridge
Wake Forest Baptist Health - Wilkes Medical Center
Wilkesboro
Divine Providence Hospital
Williamsport
Rice Memorial Hospital
Willmar
Asplundh Cancer Pavilion
Willow Grove
Christiana Care Health System-Wilmington Hospital
Wilmington
Wake Forest University Health Sciences
Winston-Salem
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids
Minnesota Oncology Hematology PA-Woodbury
Woodbury
Woodland Memorial Hospital
Woodland
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima
Avera Cancer Institute at Yankton
Yankton
UPMC Memorial
York
Saint Elizabeth Youngstown Hospital
Youngstown
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti

Fuente Oficial

Ver en ClinicalTrials.gov