/**
 * CRC Warriors - Clinical Trials Explorer
 * Theme: Blue palette (unified)
 * Version: 2.0
 */

/* ===== CSS Variables =====
 * Todas las variables que admin puede sobrescribir desde page_theme_map.php
 * (entrada 'clinical-trials.php', 21 vars). Preservar nombres EXACTOS — no
 * renombrar con prefijos: el override admin viene por nombre exacto vía DB.
 *
 * Las 3 últimas (violet-dark, violet-light, bg-light) NO están en
 * page_theme_map.php pero las dejo por compatibilidad con código futuro;
 * su valor refleja la paleta blue actual.
 */
:root {
    --amber: #0891b2;
    --amber-light: #06b6d4;
    --bg-body: #f8fafc;
    --blue: #3b82f6;
    --border: #e2e8f0;
    --border-color: #e2e8f0;
    --green: #0369a1;
    --pink: #0284c7;
    --pink-light: #0ea5e9;
    --primary: #3b82f6;
    --primary-dark: #1d4ed8;
    --red: #ef4444;
    --teal: #0056a3;
    --teal-dark: #1e3a5f;
    --teal-light: #0284c7;
    --text-dark: #1e293b;
    --text-muted: #64748b;
    --text-primary: #1e293b;
    --text-secondary: #64748b;
    --violet: #2563eb;
    --violet-dark: #1d4ed8;
    --violet-light: #3b82f6;
    --bg-light: #f8fafc;
}

/* ===== Hero Section ===== */
.hero-section {
    background: linear-gradient(135deg, var(--primary) 0%, var(--primary-dark) 100%);
    padding: 3rem 0;
    color: white;
    position: relative;
    overflow: hidden;
    margin-bottom: 2rem;
}

.hero-section::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: radial-gradient(circle at 20% 50%, rgba(255,255,255,0.1) 0%, transparent 50%);
    animation: float 15s ease-in-out infinite;
}

@keyframes float {
    0%, 100% { transform: translate(0, 0); }
    50% { transform: translate(20px, -20px); }
}

.hero-section h1 {
    font-size: 2.5rem;
    font-weight: 800;
    margin-bottom: 0.5rem;
    position: relative;
    z-index: 2;
}

.hero-section h1 i {
    margin-right: 0.5rem;
}

.hero-section .lead {
    font-size: 1.25rem;
    opacity: 0.95;
    position: relative;
    z-index: 2;
}

.hero-section .badge {
    font-size: 0.9rem;
    padding: 0.5rem 1rem;
    border-radius: 50px;
}

.hero-section .btn-light {
    background: white;
    color: var(--text-dark);
    border: none;
    font-weight: 700;
    border-radius: 50px;
    padding: 0.75rem 1.5rem;
    transition: all 0.3s;
}

.hero-section .btn-light:hover {
    transform: translateY(-3px);
    box-shadow: 0 10px 30px rgba(25,135,84,1);
    color: var(--green);
}

.hero-section .btn-outline-light {
    border: 2px solid rgba(255,255,255,0.5);
    border-radius: 50px;
    font-weight: 600;
    padding: 0.75rem 1.5rem;
}

.hero-section .btn-outline-light:hover {
    background: rgba(255,255,255,0.2);
    border-color: white;
}

/* ===== Statistics Container ===== */
.stats-container {
    margin-bottom: 2rem;
}

.stat-card {
    background: white;
    border: 2px solid var(--border);
    border-radius: 20px;
    padding: 1.5rem;
    margin-bottom: 1rem;
    position: relative;
    overflow: hidden;
    transition: all 0.3s ease;
}

.stat-card:hover {
    transform: translateY(-5px);
    box-shadow: 0 15px 40px rgba(139, 92, 246, 0.15);
}

.stat-card.primary {
    border-left: 4px solid var(--violet);
}

.stat-card.primary:hover {
    border-color: var(--violet);
}

.stat-card.success {
    border-left: 4px solid var(--teal);
}

.stat-card.success:hover {
    border-color: var(--teal);
}

.stat-card.info {
    border-left: 4px solid var(--pink);
}

.stat-card.info:hover {
    border-color: var(--pink);
}

.stat-card.warning {
    border-left: 4px solid var(--amber);
}

.stat-card.warning:hover {
    border-color: var(--amber);
}

.stat-number {
    font-size: 2.5rem;
    font-weight: 800;
    background: linear-gradient(135deg, var(--teal), var(--violet));
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
    line-height: 1;
}

.stat-card.success .stat-number {
    background: linear-gradient(135deg, var(--teal), var(--teal-light));
    -webkit-background-clip: text;
    background-clip: text;
}

.stat-card.info .stat-number {
    background: linear-gradient(135deg, #ef4444, #dc2626);
    -webkit-background-clip: text;
    background-clip: text;
}

.stat-card.warning .stat-number {
    background: linear-gradient(135deg, var(--amber), var(--amber-light));
    -webkit-background-clip: text;
    background-clip: text;
}

.stat-label {
    font-size: 0.9rem;
    font-weight: 600;
    color: var(--text-muted);
    margin-top: 0.25rem;
}

.stat-card i.position-absolute {
    color: var(--violet);
}

/* ===== Search Section ===== */
.search-section {
    background: white;
    border: 2px solid var(--border);
    border-radius: 24px;
    padding: 2rem;
    margin-bottom: 2rem;
    box-shadow: 0 10px 40px rgba(0,0,0,0.05);
    transition: border-color 0.3s;
}

.search-section:hover {
    border-color: var(--violet);
}

.search-section h3 {
    font-weight: 800;
    color: var(--text-dark);
}

.search-section h3 i {
    color: var(--violet);
}

.search-section .form-control {
    border: 2px solid var(--border);
    border-radius: 50px;
    padding: 1rem 1.5rem 1rem 3rem;
    font-size: 1rem;
    transition: all 0.3s;
}

.search-section .form-control:focus {
    border-color: var(--violet);
    box-shadow: 0 0 0 4px rgba(139, 92, 246, 0.15);
}

.search-section .btn-primary {
    background: #0d6efd;
    border: none;
    border-radius: 50px;
    font-weight: 700;
    padding: 1rem 2rem;
    transition: all 0.3s;
}

.search-section .btn-primary:hover {
    transform: translateY(-3px);
    box-shadow: 0 10px 30px rgba(13, 110, 253, 0.3);
}

/* ===== Quick Filters ===== */
.filter-badge {
    border: 2px solid var(--border);
    border-radius: 50px;
    padding: 0.5rem 1rem;
    font-weight: 600;
    transition: all 0.3s;
    background: white;
    color: var(--text-dark);
}

.filter-badge.btn-outline-primary {
    border-color: var(--violet);
    color: var(--violet);
}

.filter-badge:hover {
    border-color: var(--violet);
    background: linear-gradient(135deg, #eff6ff, #dbeafe);
    color: var(--violet) !important;
}

.filter-badge.btn-outline-primary:hover {
    background: linear-gradient(135deg, #eff6ff, #dbeafe);
    border-color: var(--violet);
    color: var(--violet) !important;
}

.filter-badge.active,
.filter-badge:active {
    background: linear-gradient(135deg, var(--violet), var(--pink));
    border-color: var(--violet);
    color: white;
}

.filter-badge[data-filter="medication"] {
    border-color: var(--teal);
}

.filter-badge[data-filter="medication"]:hover {
    background: linear-gradient(135deg, #eff6ff, #bfdbfe);
    color: var(--teal) !important;
}

/* Tumor-Agnostic (success) hover */
.filter-badge.btn-outline-success:hover {
    background: linear-gradient(135deg, #dbeafe, #93c5fd);
    border-color: var(--teal);
    color: #1e40af !important;
}

/* New Trials (danger) hover */
.filter-badge.btn-outline-danger:hover {
    background: linear-gradient(135deg, #fee2e2, #fecaca);
    border-color: var(--red);
    color: #991b1b !important;
}

/* Info (medications like Pembrolizumab) hover */
.filter-badge.btn-outline-info:hover {
    background: linear-gradient(135deg, #eff6ff, #bfdbfe);
    border-color: var(--teal);
    color: var(--teal-dark) !important;
}

.filter-badge .bi-circle-fill.text-success {
    color: var(--teal) !important;
}

/* ===== Advanced Filters Card ===== */
.card {
    border: 2px solid var(--border);
    border-radius: 20px;
    overflow: hidden;
    box-shadow: 0 5px 20px rgba(0,0,0,0.05);
}

.card:hover {
    border-color: var(--violet);
}

.card-header.bg-light {
    background: linear-gradient(135deg, #eff6ff, #dbeafe) !important;
    border-bottom: 2px solid var(--border);
    padding: 1.25rem 1.5rem;
}

.card-header h4, .card-header h5 {
    font-weight: 800;
    color: var(--text-dark);
}

.card-header h4 i, .card-header h5 i {
    color: var(--violet);
}

.card-body {
    padding: 1.5rem;
}

/* ===== Form Controls ===== */
.form-label {
    font-weight: 700;
    color: var(--text-dark);
    margin-bottom: 0.5rem;
}

.form-select, .form-control {
    border: 2px solid var(--border);
    border-radius: 12px;
    padding: 0.75rem 1rem;
    transition: all 0.3s;
}

.form-select:focus, .form-control:focus {
    border-color: var(--violet);
    box-shadow: 0 0 0 4px rgba(139, 92, 246, 0.15);
}

.form-check-input:checked {
    background-color: var(--violet);
    border-color: var(--violet);
}

.form-check-input:focus {
    box-shadow: 0 0 0 4px rgba(139, 92, 246, 0.15);
}

/* ===== Genetic Filters Card ===== */
.card.border-primary {
    border-color: var(--violet) !important;
}

.card-header.bg-primary {
    background: linear-gradient(135deg, var(--teal), var(--violet)) !important;
    border: none;
}

.card-header.bg-primary h5 {
    color: white;
}

.card-header.bg-primary small {
    color: rgba(255,255,255,0.8);
}

/* ===== Eligibility Filters ===== */
.eligibility-filters-container {
    background: linear-gradient(135deg, #eff6ff, #dbeafe);
    border: 2px solid var(--border);
    border-radius: 16px;
    overflow: hidden;
    margin-bottom: 1.5rem;
}

.eligibility-header {
    background: linear-gradient(135deg, var(--teal), var(--violet));
    color: white;
    padding: 1rem 1.5rem;
}

.eligibility-header h5 {
    font-weight: 700;
    margin: 0;
}

.eligibility-header small {
    opacity: 0.9;
}

.eligibility-body {
    padding: 1.5rem;
    background: white;
}

.filter-section {
    background: #f8fafc;
    border: 2px solid var(--border);
    border-radius: 12px;
    padding: 1rem;
    height: 100%;
}

.filter-section h6 {
    font-weight: 700;
    color: var(--text-dark);
    margin-bottom: 1rem;
}

.filter-section h6 i {
    color: var(--violet);
}

.filter-checkbox-group {
    display: flex;
    flex-direction: column;
    gap: 0.5rem;
}

.age-range-badge {
    background: linear-gradient(135deg, #eff6ff, #dbeafe);
    color: var(--violet);
    font-size: 0.75rem;
    padding: 0.2rem 0.5rem;
    border-radius: 20px;
    margin-left: 0.5rem;
}

/* ===== MSI and Tumor Agnostic Filters ===== */
.msi-filter-container,
.tumor-agnostic-filter-container {
    background: white;
    border: 2px solid var(--border);
    border-radius: 16px;
    padding: 1.5rem;
    transition: border-color 0.3s;
}

.msi-filter-container:hover,
.tumor-agnostic-filter-container:hover {
    border-color: var(--violet);
}

.tumor-agnostic-checkbox {
    background: linear-gradient(135deg, #eff6ff, #dbeafe);
    border-radius: 10px;
    padding: 0.75rem 1rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

/* ===== Action Buttons ===== */
.btn-match-profile {
    background: #0d6efd;
    border: none;
    color: white;
    font-weight: 700;
    border-radius: 50px;
    padding: 0.75rem 1.5rem;
    transition: all 0.3s;
}

.btn-match-profile:hover {
    background: #0b5ed7 !important;
    transform: translateY(-3px);
    box-shadow: 0 10px 30px rgba(13, 110, 253, 0.35);
    color: white !important;
}

.btn-match-profile:disabled {
    background: #9ca3af;
}

#applyFilters {
    background: #0d6efd;
    border: none;
    border-radius: 50px;
    font-weight: 700;
    padding: 0.75rem 2rem;
    transition: all 0.3s;
}

#applyFilters:hover {
    transform: translateY(-3px);
    box-shadow: 0 10px 30px rgba(13, 110, 253, 0.35);
}

#clearFilters {
    border: 2px solid var(--border);
    border-radius: 50px;
    font-weight: 600;
    transition: all 0.3s;
}

#clearFilters:hover {
    border-color: var(--red);
    color: var(--red);
}

/* ===== Quick Add Mutations ===== */
.quick-add-mutation {
    border: 2px solid var(--border);
    border-radius: 50px;
    font-weight: 600;
    transition: all 0.3s;
}

.quick-add-mutation:hover {
    background: linear-gradient(135deg, var(--teal), var(--violet));
    border-color: var(--violet);
    color: white;
}

/* ===== Active Filters Indicator ===== */
#activeFiltersIndicator {
    background: linear-gradient(135deg, #eff6ff, #dbeafe);
    border: 2px solid var(--border);
    border-radius: 12px;
    padding: 1rem;
}

#activeFiltersTags .badge {
    background: linear-gradient(135deg, var(--violet), var(--pink));
    font-weight: 600;
    padding: 0.5rem 1rem;
    border-radius: 50px;
    font-size: 0.85rem;
}

/* ===== Quick Stats Bar ===== */
.quick-stats-bar {
    background: linear-gradient(135deg, var(--teal), var(--violet));
    border-radius: 16px;
    padding: 1.5rem;
    display: flex;
    justify-content: space-around;
    flex-wrap: wrap;
    gap: 1rem;
    margin-bottom: 1.5rem;
}

.quick-stat {
    text-align: center;
    color: white;
}

.quick-stat-value {
    font-size: 2rem;
    font-weight: 800;
}

.quick-stat-label {
    font-size: 0.85rem;
    opacity: 0.9;
}

/* ===== Results Controls ===== */
.results-controls {
    background: white;
    border: 2px solid var(--border);
    border-radius: 16px;
    padding: 1rem 1.5rem;
    margin-bottom: 1.5rem;
    display: flex;
    justify-content: space-between;
    align-items: center;
    flex-wrap: wrap;
    gap: 1rem;
}

.sort-controls {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    flex-wrap: wrap;
}

.sort-controls label {
    font-weight: 700;
    color: var(--text-muted);
}

.sort-btn {
    padding: 0.5rem 1rem;
    border: 2px solid var(--border);
    background: white;
    border-radius: 50px;
    font-size: 0.85rem;
    font-weight: 600;
    cursor: pointer;
    transition: all 0.3s;
    display: flex;
    align-items: center;
    gap: 0.3rem;
}

.sort-btn:hover {
    border-color: var(--violet);
    background: linear-gradient(135deg, #eff6ff, #dbeafe);
}

.sort-btn.active {
    background: linear-gradient(135deg, var(--violet), var(--pink));
    color: white;
    border-color: var(--violet);
}

.view-btn {
    padding: 0.5rem 0.75rem;
    border: 2px solid var(--border);
    background: white;
    border-radius: 10px;
    cursor: pointer;
    transition: all 0.3s;
}

.view-btn:hover {
    border-color: var(--violet);
}

.view-btn.active {
    background: linear-gradient(135deg, var(--teal), var(--violet));
    color: white;
    border-color: var(--teal);
}

/* ===== Trial Cards ===== */
.trial-card {
    background: white;
    border: 2px solid var(--border);
    border-radius: 20px;
    padding: 1.5rem;
    margin-bottom: 1rem;
    transition: all 0.3s ease;
    position: relative;
}

.trial-card:hover {
    border-color: var(--violet);
    transform: translateY(-5px);
    box-shadow: 0 15px 40px rgba(139, 92, 246, 0.15);
}

.trial-card h5 {
    font-weight: 700;
    color: var(--text-dark);
    margin-bottom: 0.75rem;
}

.trial-card h5 a {
    color: var(--text-dark);
    text-decoration: none;
    transition: color 0.3s;
}

.trial-card h5 a:hover {
    color: var(--violet);
}

.trial-meta {
    display: flex;
    flex-wrap: wrap;
    gap: 1rem;
    margin-bottom: 1rem;
}

.trial-meta span {
    display: flex;
    align-items: center;
    gap: 0.3rem;
    font-size: 0.9rem;
    color: var(--text-muted);
}

.trial-meta i {
    color: var(--violet);
}

.trial-status {
    display: inline-block;
    padding: 0.35rem 0.75rem;
    border-radius: 50px;
    font-size: 0.85rem;
    font-weight: 600;
}

.trial-status.recruiting {
    background: linear-gradient(135deg, #dbeafe, #93c5fd);
    color: #1e40af;
}

.trial-status.active {
    background: linear-gradient(135deg, #e0f2fe, #7dd3fc);
    color: #92400e;
}

.trial-status.completed {
    background: linear-gradient(135deg, #e0e7ff, #c7d2fe);
    color: #3730a3;
}

.trial-status.not-recruiting {
    background: #f1f5f9;
    color: var(--text-muted);
}

/* ===== Match Score Badge ===== */
.match-score-badge {
    position: absolute;
    top: 1rem;
    right: 1rem;
    padding: 0.5rem 1rem;
    border-radius: 50px;
    font-weight: 700;
    font-size: 0.85rem;
}

.match-score-badge.high {
    background: linear-gradient(135deg, var(--teal), var(--teal-light));
    color: white;
}

.match-score-badge.medium {
    background: linear-gradient(135deg, var(--amber), var(--amber-light));
    color: #78350f;
}

.match-score-badge.low {
    background: #f1f5f9;
    color: var(--text-muted);
}

/* ===== Compact View ===== */
.results-compact .trial-card {
    padding: 1rem;
    border-radius: 12px;
}

.results-compact .trial-card h5 {
    font-size: 0.95rem;
    margin-bottom: 0.25rem;
}

.results-compact .trial-meta {
    font-size: 0.8rem;
}

/* ===== Trial Actions ===== */
.trial-actions {
    display: flex;
    gap: 0.5rem;
    flex-wrap: wrap;
    margin-top: 1rem;
}

.trial-actions .btn {
    border-radius: 50px;
    font-weight: 600;
    font-size: 0.85rem;
    padding: 0.5rem 1rem;
}

.trial-actions .btn-outline-primary {
    border: 2px solid var(--violet);
    color: var(--violet);
}

.trial-actions .btn-outline-primary:hover {
    background: linear-gradient(135deg, var(--violet), var(--pink));
    border-color: var(--violet);
    color: white;
}

.trial-actions .btn-outline-success {
    border: 2px solid var(--teal);
    color: var(--teal);
}

.trial-actions .btn-outline-success:hover {
    background: linear-gradient(135deg, var(--teal), var(--teal-light));
    border-color: var(--teal);
    color: white;
}

/* ===== Pagination ===== */
.pagination {
    gap: 0.25rem;
}

.page-link {
    border: 2px solid var(--border);
    border-radius: 10px;
    color: var(--text-dark);
    font-weight: 600;
    padding: 0.5rem 1rem;
    transition: all 0.3s;
}

.page-link:hover {
    border-color: var(--violet);
    background: linear-gradient(135deg, #eff6ff, #dbeafe);
    color: var(--violet);
}

.page-item.active .page-link {
    background: linear-gradient(135deg, var(--violet), var(--pink));
    border-color: var(--violet);
    color: white;
}

.page-item.disabled .page-link {
    background: #f8fafc;
    color: var(--text-muted);
}

/* ===== Modal ===== */
.modal-content {
    border: none;
    border-radius: 24px;
    overflow: hidden;
}

.modal-header.bg-primary {
    background: linear-gradient(135deg, var(--teal), var(--violet)) !important;
    border: none;
    padding: 1.5rem;
}

.modal-header .modal-title {
    font-weight: 800;
}

.modal-body {
    padding: 2rem;
}

.modal-footer {
    border-top: 2px solid var(--border);
    padding: 1.25rem 1.5rem;
    gap: 0.5rem;
}

.modal-footer .btn {
    border-radius: 50px;
    font-weight: 600;
}

/* ===== Loading Overlay ===== */
.loading-overlay {
    position: fixed;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: rgba(255,255,255,0.95);
    display: none;
    justify-content: center;
    align-items: center;
    z-index: 9999;
}

.loading-overlay.show {
    display: flex;
}

.loading-overlay .spinner-border {
    color: var(--violet) !important;
}

/* ===== Alerts ===== */
.alert-info {
    background: linear-gradient(135deg, #eff6ff, #dbeafe);
    border: 2px solid var(--violet);
    border-radius: 16px;
    color: var(--text-dark);
}

.alert-info i {
    color: var(--violet);
}

#activeFiltersBanner {
    background: linear-gradient(135deg, #eff6ff, #dbeafe);
    border: 2px solid var(--violet);
    border-radius: 16px;
}

#activeFiltersBanner .badge {
    background: linear-gradient(135deg, var(--violet), var(--pink));
}

/* ===== Medication Filter ===== */
.medication-sync-status.synced {
    color: var(--teal);
}

.medication-sync-status.syncing {
    color: var(--amber);
}

.medication-sync-status.error {
    color: var(--red);
}

.medication-filter-info {
    background: linear-gradient(135deg, #eff6ff, #dbeafe);
    border-left: 4px solid var(--teal);
    border-radius: 0 12px 12px 0;
    padding: 0.75rem 1rem;
    margin-bottom: 1rem;
}

.medication-filter-info a {
    color: var(--violet);
    font-weight: 600;
}

/* ===== Table ===== */
.table {
    border-radius: 12px;
    overflow: hidden;
}

.table thead th {
    background: #003d7a;
    color: white;
    font-weight: 700;
    border: none;
    padding: 1rem;
}

.table tbody td {
    padding: 0.75rem 1rem;
    border-color: var(--border);
    vertical-align: middle;
}

.table tbody tr:hover {
    background: linear-gradient(135deg, #eff6ff, #dbeafe);
}

/* ===== Badges ===== */
.badge.bg-danger {
    background: linear-gradient(135deg, var(--red), #f87171) !important;
}

.badge.bg-info {
    background: linear-gradient(135deg, var(--teal), var(--teal-light)) !important;
}

.badge.bg-primary {
    background: linear-gradient(135deg, var(--violet), var(--pink)) !important;
}

.badge.bg-success {
    background: linear-gradient(135deg, var(--teal), var(--green)) !important;
}

/* ===== New Trial Indicator ===== */
.new-trial-badge {
    background: linear-gradient(135deg, #ef4444, #dc2626);
    color: white;
    font-size: 0.75rem;
    padding: 0.25rem 0.5rem;
    border-radius: 50px;
    font-weight: 700;
    animation: pulse 2s infinite;
}

@keyframes pulse {
    0%, 100% { opacity: 1; }
    50% { opacity: 0.7; }
}

/* ===== Responsive — Small phones (≤480px) ===== */
@media (max-width: 480px) {
    .hero-section h1 {
        font-size: 1.35rem;
    }
    
    .hero-section .lead {
        font-size: 0.95rem;
    }
    
    .hero-section .btn-lg {
        padding: 0.6rem 1rem;
        font-size: 0.85rem;
    }
    
    .stat-number {
        font-size: 1.5rem;
    }
    
    .stat-label {
        font-size: 0.75rem;
    }
    
    .stat-card {
        padding: 1rem;
        border-radius: 14px;
    }
    
    .search-section {
        padding: 1rem;
        border-radius: 16px;
    }
    
    .search-section .form-control {
        padding: 0.75rem 1rem 0.75rem 2.5rem;
        font-size: 0.9rem;
    }
    
    .search-section .btn-primary {
        padding: 0.75rem 1rem;
        font-size: 0.9rem;
    }
    
    .filter-badge {
        padding: 0.35rem 0.7rem;
        font-size: 0.75rem;
    }
    
    .quick-stat-value {
        font-size: 1.5rem;
    }
    
    .quick-stat-label {
        font-size: 0.75rem;
    }
    
    .trial-card {
        padding: 1rem;
        border-radius: 14px;
    }
    
    .trial-card h5 {
        font-size: 0.95rem;
    }
    
    .trial-meta {
        gap: 0.5rem;
    }
    
    .trial-meta span {
        font-size: 0.8rem;
    }
    
    .eligibility-badge {
        font-size: 0.65rem !important;
        padding: 2px 6px !important;
    }
    
    /* Map smaller on very small screens */
    #trialMap,
    .map-loading {
        height: 250px !important;
    }
    
    /* Modal nearly full screen */
    .modal-dialog.modal-xl {
        margin: 0.25rem;
    }
    
    .modal-body {
        padding: 1rem;
    }
    
    .modal-header {
        padding: 1rem;
    }
    
    .modal-header .modal-title {
        font-size: 0.95rem;
    }
    
    /* Pagination compact */
    .page-link {
        padding: 0.35rem 0.65rem;
        font-size: 0.85rem;
    }
}

/* ===== Responsive — Tablets & phones (≤768px) ===== */
@media (max-width: 768px) {
    .hero-section {
        padding: 1.5rem 0;
    }
    
    .hero-section h1 {
        font-size: 1.5rem;
    }
    
    .hero-section .lead {
        font-size: 1rem;
    }
    
    /* Hero buttons — stack on mobile */
    .hero-section .col-lg-4 {
        margin-top: 1rem;
    }
    
    .hero-section .btn-lg {
        padding: 0.65rem 1.2rem;
        font-size: 0.9rem;
    }
    
    .hero-section .btn-lg.ms-2 {
        margin-left: 0 !important;
        margin-top: 0.5rem;
    }
    
    .stat-number {
        font-size: 1.75rem;
    }
    
    .stat-card {
        padding: 1.15rem;
    }
    
    .search-section {
        padding: 1.25rem;
        border-radius: 16px;
    }
    
    .search-section .form-control {
        padding: 0.75rem 1rem 0.75rem 2.5rem;
    }
    
    .results-controls {
        flex-direction: column;
        align-items: stretch;
        padding: 0.75rem 1rem;
    }
    
    .sort-controls {
        justify-content: center;
        flex-wrap: wrap;
    }
    
    .quick-stats-bar {
        flex-direction: column;
        padding: 1rem;
        gap: 0.75rem;
    }
    
    .quick-stats-bar .quick-stat {
        display: flex;
        justify-content: space-between;
        align-items: center;
        text-align: left;
    }
    
    .quick-stat-value {
        font-size: 1.75rem;
    }
    
    /* Trial cards — make status/buttons full-width left-aligned */
    .trial-card {
        padding: 1.15rem;
    }
    
    .trial-card .col-lg-3 {
        text-align: left !important;
        margin-top: 0.75rem;
        padding-top: 0.75rem;
        border-top: 1px solid var(--border);
        display: flex;
        flex-wrap: wrap;
        align-items: center;
        gap: 0.5rem;
    }
    
    .trial-card .col-lg-3 .badge {
        margin-bottom: 0 !important;
    }
    
    .trial-card .col-lg-3 .mt-3 {
        margin-top: 0 !important;
        margin-left: auto;
    }
    
    .trial-card .d-flex.flex-wrap.gap-1 {
        justify-content: flex-start;
    }
    
    .match-score-badge {
        position: static;
        display: inline-block;
        margin-bottom: 0.75rem;
    }
    
    /* Map height */
    #trialMap,
    .map-loading {
        height: 300px !important;
    }
    
    .map-toggle-btn {
        padding: 10px 14px;
        font-size: 0.9rem;
    }
    
    /* Modal footer — wrap buttons */
    .modal-footer {
        flex-wrap: wrap;
        gap: 0.4rem;
        padding: 0.75rem 1rem;
    }
    
    .modal-footer .btn {
        font-size: 0.8rem;
        padding: 0.4rem 0.75rem;
    }
    
    .modal-body {
        padding: 1.25rem;
    }
    
    /* Genetic Alterations Table - Mobile Responsive */
    #alterationsTable {
        display: block;
    }
    
    #alterationsTable thead {
        display: none;
    }
    
    #alterationsTable tbody {
        display: block;
    }
    
    #alterationsTable tbody tr {
        display: block;
        background: white;
        border: 2px solid var(--border);
        border-radius: 12px;
        margin-bottom: 1rem;
        padding: 1rem;
        position: relative;
    }
    
    #alterationsTable tbody tr:hover {
        border-color: var(--teal);
    }
    
    #alterationsTable tbody td {
        display: block;
        padding: 0.5rem 0;
        border: none;
        text-align: left;
    }
    
    #alterationsTable tbody td:before {
        content: attr(data-label);
        display: block;
        font-weight: 700;
        font-size: 0.75rem;
        color: var(--teal);
        text-transform: uppercase;
        margin-bottom: 0.25rem;
    }
    
    #alterationsTable tbody td select {
        width: 100%;
    }
    
    /* Actions cell - horizontal layout */
    #alterationsTable tbody td:last-child {
        display: flex;
        gap: 0.5rem;
        flex-wrap: wrap;
        padding-top: 1rem;
        margin-top: 0.5rem;
        border-top: 1px solid var(--border);
    }
    
    #alterationsTable tbody td:last-child:before {
        display: none;
    }
    
    #alterationsTable tbody td:last-child .btn {
        flex: 1;
        min-width: 80px;
    }
    
    /* Card header */
    .card-header.bg-primary {
        padding: 1rem;
    }
    
    .card-header.bg-primary h5 {
        font-size: 1rem;
    }
    
    .card-header.bg-primary small {
        font-size: 0.75rem;
    }
    
    /* Alert info box */
    .card-body .alert-info {
        font-size: 0.85rem;
        padding: 0.75rem;
    }
    
    .card-body .alert-info br {
        display: none;
    }
    
    /* Quick add buttons */
    .quick-add-mutation {
        font-size: 0.8rem;
        padding: 0.4rem 0.8rem;
    }
    
    /* Advanced filter selects */
    .eligibility-body .col-md-3 {
        margin-bottom: 0.75rem;
    }
    
    /* Medication dropdown */
    .medication-dropdown {
        max-height: 200px;
    }
    
    /* Sort buttons compact */
    .sort-btn {
        padding: 0.4rem 0.7rem;
        font-size: 0.8rem;
    }
}

/* ===== Responsive — Medium screens / small tablets (≤992px) ===== */
@media (max-width: 992px) {
    /* Trial card right column — when col-lg-3 unstacks */
    .trial-card .row > .col-lg-3.text-end {
        text-align: left !important;
    }
    
    /* Hero section buttons wrap */
    .hero-section .col-lg-4 {
        display: flex;
        flex-wrap: wrap;
        gap: 0.5rem;
    }
    
    /* Search section button full width when unstacked */
    .search-section .col-lg-3 .btn {
        margin-top: 0.75rem;
    }
}

/* ===== NEW Badge ===== */
.new-badge {
    display: inline-block;
    background: linear-gradient(135deg, #ef4444, #f87171);
    color: white;
    padding: 0.2rem 0.6rem;
    border-radius: 50px;
    font-size: 0.65rem;
    font-weight: 700;
    text-transform: uppercase;
    letter-spacing: 0.5px;
    margin-left: 0.5rem;
    vertical-align: middle;
    box-shadow: 0 2px 8px rgba(239, 68, 68, 0.35);
    animation: pulse-new 2s infinite;
}

@keyframes pulse-new {
    0%, 100% { transform: scale(1); }
    50% { transform: scale(1.05); }
}

/* ===== Print Styles ===== */
@media print {
    .hero-section,
    .search-section,
    .card,
    .results-controls,
    .pagination,
    .trial-actions,
    #quickStats {
        display: none !important;
    }
    
    .trial-card {
        break-inside: avoid;
        border: 1px solid #ccc;
        box-shadow: none;
    }
}

/* ===== Phase Badge ===== */
.phase-badge {
    background: linear-gradient(135deg, #3b82f6, #2563eb) !important;
    color: white !important;
    font-weight: 600;
    padding: 0.35rem 0.75rem;
    border: none;
}

/* ===== Medication Badge ===== */
.medication-badge {
    background: linear-gradient(135deg, #0ea5e9, #0284c7) !important;
    color: white !important;
    font-weight: 500;
    padding: 0.3rem 0.6rem;
    border: none;
}

/* ===== Status Badges ===== */
.status-badge-success {
    background: #10b981 !important;
    color: white !important;
    box-shadow: 0 0 0 1px rgba(5, 150, 105, 0.2) !important;
}
.status-badge-success::before {
    content: "\F287";
    font-family: "bootstrap-icons";
    font-size: 0.55em;
    margin-right: 4px;
    color: #ffffff;
    animation: ct-pulse 2s ease-in-out infinite;
}
@keyframes ct-pulse {
    0%, 100% { opacity: 1; }
    50% { opacity: 0.55; }
}
.status-badge-warning {
    background: #f59e0b !important;
    color: white !important;
}
.status-badge-danger {
    background: #ef4444 !important;
    color: white !important;
}
.status-badge-primary {
    background: #3b82f6 !important;
    color: white !important;
}
.status-badge-secondary {
    background: #6b7280 !important;
    color: white !important;
}
.status-badge-info {
    background: #06b6d4 !important;
    color: white !important;
}


/* ============================================================
 * G2 Sub-lote 3A — Reglas migradas desde el bloque <style>
 * inline que estaba en clinical-trials.php (líneas ~163-403).
 * Mantienen el mismo orden y semántica originales.
 * ============================================================ */

.medication-search-wrapper { position: relative; }
.medication-search-wrapper input { padding-left: 2.5rem; }
.medication-search-wrapper::before {
    content: "\F52A";
    font-family: 'bootstrap-icons';
    position: absolute;
    left: 1rem;
    top: 50%;
    transform: translateY(-50%);
    color: #6c757d;
    z-index: 1;
}
#medicationFilter optgroup { font-weight: bold; }
#medicationFilter optgroup option { font-weight: normal; padding-left: 1.5rem; }

/* ===== NEW Badge ===== */
.new-badge {
    display: inline-block;
    background: linear-gradient(135deg, #ef4444, #dc2626);
    color: white;
    padding: 0.2rem 0.6rem;
    border-radius: 50px;
    font-size: 0.65rem;
    font-weight: 700;
    text-transform: uppercase;
    letter-spacing: 0.5px;
    margin-left: 0.5rem;
    vertical-align: middle;
    box-shadow: 0 2px 8px rgba(239, 68, 68, 0.35);
    animation: pulse-new 2s infinite;
}

@keyframes pulse-new {
    0%, 100% { transform: scale(1); }
    50% { transform: scale(1.05); }
}

/* Fix: Asegurar que botones del hero sean clickeables */
.hero-section::before,
.hero-section::after {
    pointer-events: none !important;
}
.hero-section .btn {
    position: relative;
    z-index: 10;
    pointer-events: auto !important;
}

/* ===== Translation Button ===== */

/* ===== Multi-select Medication Component ===== */
.medication-multi-select {
    position: relative;
    border: 1px solid #dee2e6;
    border-radius: 0.375rem;
    padding: 0.25rem;
    min-height: 38px;
    background: #fff;
    cursor: text;
}
.medication-multi-select:focus-within {
    border-color: #86b7fe;
    box-shadow: 0 0 0 0.25rem rgba(13, 110, 253, 0.25);
}
.medication-chips {
    display: flex;
    flex-wrap: wrap;
    gap: 4px;
    margin-bottom: 2px;
}
.medication-chip {
    display: inline-flex;
    align-items: center;
    background: #dbeafe;
    color: #0d6efd;
    border: 1px solid #b6d4fe;
    border-radius: 50px;
    padding: 2px 8px 2px 10px;
    font-size: 0.78rem;
    font-weight: 500;
    white-space: nowrap;
}
.medication-chip .chip-remove {
    margin-left: 4px;
    cursor: pointer;
    font-weight: bold;
    opacity: 0.7;
    font-size: 0.9rem;
    line-height: 1;
}
.medication-chip .chip-remove:hover { opacity: 1; color: #dc3545; }
.medication-multi-select input {
    border: none !important;
    outline: none !important;
    box-shadow: none !important;
    padding: 2px 4px !important;
    font-size: 0.85rem;
    width: 100%;
    min-width: 80px;
}
.medication-dropdown {
    position: absolute;
    top: 100%;
    left: 0;
    right: 0;
    background: #fff;
    border: 1px solid #dee2e6;
    border-radius: 0 0 0.375rem 0.375rem;
    max-height: 250px;
    overflow-y: auto;
    z-index: 1050;
    box-shadow: 0 4px 12px rgba(0,0,0,0.15);
}
.medication-dropdown .med-option {
    padding: 6px 12px;
    cursor: pointer;
    font-size: 0.85rem;
    border-bottom: 1px solid #f0f0f0;
}
.medication-dropdown .med-option:hover { background: #dbeafe; }
.medication-dropdown .med-option.selected { background: #cfe2ff; font-weight: 600; }
.medication-dropdown .med-category {
    padding: 4px 12px;
    font-size: 0.75rem;
    font-weight: 700;
    color: #6c757d;
    background: #f8f9fa;
    text-transform: uppercase;
    letter-spacing: 0.5px;
}

/* ===== City Autocomplete ===== */

/* ===== Interactive Map ===== */
.map-section {
    margin-bottom: 1.5rem;
    border: 2px solid var(--border-color);
    border-radius: 16px;
    overflow: hidden;
    background: white;
}
.map-toggle-btn {
    width: 100%;
    padding: 12px 20px;
    background: white;
    border: none;
    display: flex;
    justify-content: space-between;
    align-items: center;
    font-weight: 600;
    color: var(--text-primary);
    cursor: pointer;
    transition: background 0.2s;
}
.map-toggle-btn:hover { background: var(--bg-body); }
.map-toggle-btn .map-badge {
    background: var(--blue);
    color: white;
    padding: 2px 10px;
    border-radius: 50px;
    font-size: 0.75rem;
}
.map-toggle-btn i.chevron { transition: transform 0.3s; }
.map-toggle-btn.collapsed i.chevron { transform: rotate(-90deg); }
#trialMap { height: 420px; width: 100%; }
.map-loading {
    display: flex;
    justify-content: center;
    align-items: center;
    height: 420px;
    color: var(--text-secondary);
}

/* ===== City Autocomplete ===== */
.city-autocomplete-dropdown {
    position: absolute;
    top: 100%;
    left: 0;
    right: 0;
    background: #fff;
    border: 1px solid #dee2e6;
    border-radius: 0 0 0.375rem 0.375rem;
    max-height: 250px;
    overflow-y: auto;
    z-index: 1050;
    box-shadow: 0 4px 12px rgba(0,0,0,0.15);
}
.city-autocomplete-dropdown .city-option {
    padding: 8px 12px;
    cursor: pointer;
    font-size: 0.85rem;
    border-bottom: 1px solid #f0f0f0;
    display: flex;
    justify-content: space-between;
    align-items: center;
}
.city-autocomplete-dropdown .city-option:hover { background: #dbeafe; }
.city-autocomplete-dropdown .city-option .city-count {
    font-size: 0.7rem;
    color: #6c757d;
    background: #f0f0f0;
    padding: 1px 6px;
    border-radius: 10px;
}
.city-autocomplete-dropdown .city-option .city-icon {
    margin-right: 6px;
    color: #6c757d;
}

.trial-card .d-flex.flex-wrap.gap-1 {
    justify-content: flex-end;
}
.trial-card .d-flex.flex-wrap.gap-1 .btn {
    white-space: nowrap;
}



/* ============================================================
 * G2 Sub-lote 3A — Clases utility para reemplazar inline styles
 * Prefijo `ct-` (clinical-trials) para evitar colisiones.
 * ============================================================ */

/* --- Botones del hero con z-index para no quedar bajo decoración --- */
.ct-overlay-btn {
    cursor: pointer;
    position: relative;
    z-index: 10;
}

/* --- Iconos de fondo decorativos en stat cards (esquina sup-der) --- */
.ct-stat-bg-icon {
    font-size: 3rem;
    opacity: 0.1;
    right: 20px;
    top: 20px;
}

/* --- Icono lupa dentro del input de búsqueda --- */
.ct-search-input-icon {
    left: 1rem;
    top: 50%;
    transform: translateY(-50%);
    color: #6c757d;
}

/* --- Spinner grande (overlay de carga) --- */
.ct-spinner-lg {
    width: 3rem;
    height: 3rem;
}

/* --- Iconos coloreados de filtros (género, tipo, estado, etc.) ---
 * Los hex provienen del HTML original. Mantenidos literales aquí
 * para preservar exactamente la apariencia previa. Si el admin
 * añade overrides en page_theme_map.php para estos colores específicos,
 * se podrá migrar a var(--xxx).
 */
.ct-icon-blue-700  { color: #1d4ed8; } /* gender-female */
.ct-icon-blue-500  { color: #2196f3; } /* gender-male */
.ct-icon-cyan-700  { color: #0369a1; } /* activity / person-check */
.ct-icon-blue-800  { color: #1e40af; } /* eye (observational) */
.ct-icon-cyan-600  { color: #0891b2; } /* graph-up (has results) */
.ct-icon-gray-500  { color: #607d8b; } /* clock-history (no results yet) */

/* --- Anchos de columna fijos en la tabla de alteraciones --- */
.ct-col-25 { width: 25%; }
.ct-col-30 { width: 30%; }
.ct-col-20 { width: 20%; }

/* ============================================================
 * Lote G — Visual refinement (May 2026)
 * Botones de la tabla de alteraciones genéticas
 * Sustituyen btn-danger/btn-info planos por variantes definidas
 * ============================================================ */

/* Botones de acción en la fila de mutación (Eliminar / Duplicar) */
#alterationsTable .ct-action-btn {
    display: inline-flex;
    align-items: center;
    gap: 5px;
    padding: 6px 12px;
    border-radius: 7px;
    font-size: 0.82rem;
    font-weight: 500;
    line-height: 1.2;
    border: 1px solid;
    transition: all 0.15s ease;
    cursor: pointer;
    background: #ffffff;
}

#alterationsTable .ct-action-btn i {
    font-size: 0.95rem;
    line-height: 1;
}

#alterationsTable .ct-action-btn-delete {
    background: #ffffff;
    border-color: #fca5a5;
    color: #b91c1c;
}

#alterationsTable .ct-action-btn-delete:hover {
    background: #fef2f2;
    border-color: #ef4444;
    color: #991b1b;
    box-shadow: 0 1px 3px rgba(239, 68, 68, 0.18);
}

#alterationsTable .ct-action-btn-duplicate {
    background: #ffffff;
    border-color: #93c5fd;
    color: #1d4ed8;
    margin-left: 6px;
}

#alterationsTable .ct-action-btn-duplicate:hover {
    background: #eff6ff;
    border-color: #3b82f6;
    color: #1e40af;
    box-shadow: 0 1px 3px rgba(59, 130, 246, 0.18);
}

/* Override de los antiguos btn-danger/btn-info dentro del alterationsTable
 * (compat por si el JS antiguo aún emite esas clases) */
#alterationsTable .btn-danger.btn-sm {
    background: #ffffff !important;
    border: 1px solid #fca5a5 !important;
    color: #b91c1c !important;
    border-radius: 7px !important;
    font-weight: 500;
    padding: 6px 12px;
    transition: all 0.15s ease;
}

#alterationsTable .btn-danger.btn-sm:hover {
    background: #fef2f2 !important;
    border-color: #ef4444 !important;
    color: #991b1b !important;
}

#alterationsTable .btn-info.btn-sm {
    background: #ffffff !important;
    border: 1px solid #93c5fd !important;
    color: #1d4ed8 !important;
    border-radius: 7px !important;
    font-weight: 500;
    padding: 6px 12px;
    transition: all 0.15s ease;
}

#alterationsTable .btn-info.btn-sm:hover {
    background: #eff6ff !important;
    border-color: #3b82f6 !important;
    color: #1e40af !important;
}

/* Phase badge — más definido (acompaña al status-badge verde) */
.phase-badge {
    background: #e0e7ff !important;
    color: #3730a3 !important;
    font-weight: 500;
    border: 1px solid #c7d2fe;
}

/* High-match card highlight */
.trial-card.high-match {
    border-left: 3px solid #10b981;
}

/* Trial card más visual — iconos con colores semánticos */
.trial-card .trial-meta i {
    margin-right: 3px;
    color: #64748b;
}

/* Color por tipo de meta info en la card */
.trial-card .trial-meta .bi-fingerprint { color: #64748b; }   /* NCT ID — neutro */
.trial-card .trial-meta .bi-geo-alt     { color: #10b981; }   /* país — verde */
.trial-card .trial-meta .bi-calendar    { color: #f59e0b; }   /* fecha — ámbar */
.trial-card .trial-meta .bi-building    { color: #7c3aed; }   /* sponsor — púrpura */
.trial-card .trial-meta .bi-people      { color: #3b82f6; }   /* pacientes — azul */

.trial-card .trial-meta span {
    display: inline-flex;
    align-items: center;
    gap: 4px;
    font-size: 0.85rem;
}